gene

NDUFAF1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NDUFAF1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

10Outgoing

5Incoming

0Experiments

0Debates

Summary

Page for NDUFAF1 — NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1

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🧬 Gene Info

Gene Symbol	NDUFAF1
Full Name	NADH:Ubiquinone Oxidoreductase Complex Assembly Factor 1
Chromosome	16p13.3
Protein Family	AIM (Ancestral Immune Protein) family
Function	is a nuclear-encoded mitochondrial protein that plays a critical role in the biogenesis of mitochondrial Complex I, the largest enzyme of the electron transport chain.
Primary Expression	Brain, heart, skeletal muscle, liver, kidney
Subcellular Localization	Mitochondrial matrix
Molecular Weight	46 kDa
Amino Acids	90 aa
UniProt ID	[Q9P032](https://www.uniprot.org/uniprot/Q9P032)
Ensembl ID	ENSG00000166068
GeneCards	NDUFAF1
Human Protein Atlas	NDUFAF1
Associated Diseases	Ms
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NDUFAF1["<b>NDUFAF1</b>"]
    Ms{"Ms"}
    NDUFAF1 -->|"associated with"| Ms
    IMMUNE_INFILTRATION["IMMUNE INFILTRATION"]
    NDUFAF1 -->|"associated with"| IMMUNE_INFILTRATION
    neurodegeneration["neurodegeneration"]
    NDUFAF1 -->|"implicated in"| neurodegeneration
    BNIP3["BNIP3"]
    BNIP3 -->|"associated with"| NDUFAF1
    MFN1["MFN1"]
    MFN1 -->|"associated with"| NDUFAF1
    NDUFAF7["NDUFAF7"]
    NDUFAF7 -->|"associated with"| NDUFAF1
    NBR1["NBR1"]
    NBR1 -->|"associated with"| NDUFAF1
    MCC["MCC"]
    MCC -->|"associated with"| NDUFAF1
    style NDUFAF1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (10)

Target	Relation	Type	Str
Ms	associated_with	disease	0.65
IMMUNE INFILTRATION	associated_with	gene	0.60
B Cell	associated_with	cell_type	0.60
Ras	associated_with	protein	0.60
App	associated_with	protein	0.60
MFN1	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
BNIP3	associated_with	gene	0.60
MCC	associated_with	gene	0.60
NDUFAF7	associated_with	gene	0.60

Incoming (5)

Source	Relation	Type	Str
BNIP3	associated_with	gene	0.60
MFN1	associated_with	gene	0.60
NDUFAF7	associated_with	gene	0.60
NBR1	associated_with	gene	0.60
MCC	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity