gene

BNIP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BNIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1281Connections
0Hypotheses
1Analyses
50Outgoing
50Incoming

Summary

BNIP3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 615 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolBNIP3
Full NameBCL2 Interacting Protein 3
Chromosome10q26.3
Functionis a pro-apoptotic BH3-only protein that plays a dual role in regulating both apoptosis and mitophagy.
Primary ExpressionUbiquitous; high expression in brain, heart, and skeletal muscle
PathwaysApoptosis, Autophagy, Chaperone, Histone Modification, Lipid Metabolism
UniProt IDQ12986
NCBI Gene ID664
Ensembl IDENSG00000176171
OMIM604488
GeneCardsBNIP3
Human Protein AtlasBNIP3
Associated DiseasesAD, ALI, ALS, Alzheimer, Carcinoma
Known Drugs/Compoundsdimethyl fumarate
InteractionsDISC1, EIF2S1, RIPK3, DRP1, CHOP, BECN1
KG Connections1281 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: BNIP3 — AlphaFold Q12986 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

BNIP3 Gene

gene · 672 words

Mitochondrial Quality Control

mechanism · 5069 words

Mitochondrial Dysfunction in Parkinson's Disease

mechanism · 4972 words

Autophagy Mechanisms

mechanism · 4866 words

Mitophagy Pathway in Neurodegeneration

mechanism · 4637 words

mitophagy-defect

mechanism · 3933 words

Pathway Diagram

flowchart TD
    BNIP3(["BNIP3"])
    Mitophagy("Mitophagy")
    MITOPHAGY(["MITOPHAGY"])
    Autophagy["Autophagy"]
    Als["Als"]
    Ischemia["Ischemia"]
    mitophagy("mitophagy")
    Programmed_Mitophagy("Programmed Mitophagy")
    AUTOPHAGY(["AUTOPHAGY"])
    MITOCHONDRIA(["MITOCHONDRIA"])
    NIX(["NIX"])
    LC3B(["LC3B"])

    BNIP3 -->|"activates"| Mitophagy
    BNIP3 -->|"regulates"| Mitophagy
    MITOPHAGY -->|"regulates"| BNIP3
    MITOPHAGY -->|"activates"| BNIP3
    BNIP3 -->|"activates"| Autophagy
    BNIP3 -->|"activates"| Als
    BNIP3 -->|"regulates"| Ischemia
    BNIP3 -->|"participates in"| mitophagy
    BNIP3 -->|"activates"| mitophagy
    BNIP3 -->|"mediates"| Programmed_Mitophagy
    BNIP3 -->|"activates"| AUTOPHAGY
    BNIP3 -->|"activates"| MITOCHONDRIA
    BNIP3 -->|"regulates"| NIX
    BNIP3 -->|"interacts with"| LC3B
    BNIP3 -->|"involved in"| Mitophagy

    style BNIP3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (939)

TargetRelationTypeStr
Mitophagyactivatespathway1.00
Mitophagyregulatespathway1.00
Autophagyactivatespathway1.00
Alsactivatesdisease0.95
Ischemiaregulatesdisease0.95

Incoming (342)

SourceRelationTypeStr
MITOPHAGYregulatesgene1.00
MITOPHAGYactivatesgene1.00
Copperdownregulatescompound0.95
h-2a4e4ad2targets_genehypothesis0.90
SIRT1upregulatesprotein0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Mitochondrial transfer between neurons and glia

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found