Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BNIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BNIP3 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, regulates. Associated with AD, ALI, ALS. Connected to 615 entities in the SciDEX knowledge graph.
| Gene Symbol | BNIP3 |
| Full Name | BCL2 Interacting Protein 3 |
| Chromosome | 10q26.3 |
| Function | is a pro-apoptotic BH3-only protein that plays a dual role in regulating both apoptosis and mitophagy. |
| Primary Expression | Ubiquitous; high expression in brain, heart, and skeletal muscle |
| Pathways | Apoptosis, Autophagy, Chaperone, Histone Modification, Lipid Metabolism |
| UniProt ID | Q12986 |
| NCBI Gene ID | 664 |
| Ensembl ID | ENSG00000176171 |
| OMIM | 604488 |
| GeneCards | BNIP3 |
| Human Protein Atlas | BNIP3 |
| Associated Diseases | AD, ALI, ALS, Alzheimer, Carcinoma |
| Known Drugs/Compounds | dimethyl fumarate |
| Interactions | DISC1, EIF2S1, RIPK3, DRP1, CHOP, BECN1 |
| KG Connections | 1281 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
BNIP3(["BNIP3"])
Mitophagy("Mitophagy")
MITOPHAGY(["MITOPHAGY"])
Autophagy["Autophagy"]
Als["Als"]
Ischemia["Ischemia"]
mitophagy("mitophagy")
Programmed_Mitophagy("Programmed Mitophagy")
AUTOPHAGY(["AUTOPHAGY"])
MITOCHONDRIA(["MITOCHONDRIA"])
NIX(["NIX"])
LC3B(["LC3B"])
BNIP3 -->|"activates"| Mitophagy
BNIP3 -->|"regulates"| Mitophagy
MITOPHAGY -->|"regulates"| BNIP3
MITOPHAGY -->|"activates"| BNIP3
BNIP3 -->|"activates"| Autophagy
BNIP3 -->|"activates"| Als
BNIP3 -->|"regulates"| Ischemia
BNIP3 -->|"participates in"| mitophagy
BNIP3 -->|"activates"| mitophagy
BNIP3 -->|"mediates"| Programmed_Mitophagy
BNIP3 -->|"activates"| AUTOPHAGY
BNIP3 -->|"activates"| MITOCHONDRIA
BNIP3 -->|"regulates"| NIX
BNIP3 -->|"interacts with"| LC3B
BNIP3 -->|"involved in"| Mitophagy
style BNIP3 fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Mitophagy | activates | pathway | 1.00 |
| Mitophagy | regulates | pathway | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| Als | activates | disease | 0.95 |
| Ischemia | regulates | disease | 0.95 |
| Mitophagy | mediates | process | 0.95 |
| Programmed Mitophagy | mediates | process | 0.90 |
| programmed mitophagy | regulates | process | 0.90 |
| mitophagy | participates_in | pathway | 0.90 |
| mitophagy | activates | phenotype | 0.90 |
| autophagy pathway | participates_in | pathway | 0.90 |
| AUTOPHAGY | activates | gene | 0.90 |
| MITOCHONDRIA | activates | gene | 0.90 |
| NIX | regulates | gene | 0.90 |
| MITOPHAGY | mediates | process | 0.85 |
| LC3B | interacts_with | protein | 0.80 |
| Mitophagy | involved_in | process | 0.80 |
| oxidative stress response | participates_in | pathway | 0.80 |
| MITOPHAGY | downregulation_by_copper_impairs | process | 0.80 |
| GENES | activates | gene | 0.80 |
| Apoptosis | activates | pathway | 0.80 |
| Cancer | activates | disease | 0.75 |
| Als | regulates | disease | 0.75 |
| Cancer | regulates | disease | 0.75 |
| Cardiovascular | therapeutic_target | disease | 0.75 |
| Ischemia | activates | disease | 0.75 |
| Tumor | activates | disease | 0.75 |
| Cancer | therapeutic_target | disease | 0.75 |
| Inflammation | activates | disease | 0.75 |
| Cancer | inhibits | disease | 0.75 |
| PARKIN | activates | gene | 0.70 |
| ATG7 | activates | gene | 0.70 |
| neurodegeneration | activates | process | 0.70 |
| P62 | regulates | gene | 0.70 |
| PARKIN | regulates | gene | 0.70 |
| LC3 | activates | gene | 0.70 |
| Mitophagy | contributes_to | pathway | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Oxidative Stress | activates | pathway | 0.70 |
| Mitophagy | biomarker_for | pathway | 0.70 |
| MITOCHONDRIAL DYSFUNCTION | regulates | gene | 0.70 |
| AUTOPHAGY | regulates | gene | 0.70 |
| CANCER | therapeutic_target | gene | 0.70 |
| CANCER | activates | gene | 0.70 |
| CANCER | regulates | gene | 0.70 |
| APOPTOSIS | expressed_in | gene | 0.70 |
| Apoptosis | expressed_in | pathway | 0.70 |
| CANCER | inhibits | gene | 0.70 |
| NIX | contributes_to | gene | 0.70 |
| MITOCHONDRIA | regulates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MITOPHAGY | regulates | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| Copper | downregulates | compound | 0.95 |
| h-2a4e4ad2 | targets_gene | hypothesis | 0.90 |
| SIRT1 | upregulates | protein | 0.85 |
| NFKB | downregulates | protein | 0.85 |
| FOXO3 | regulates | protein | 0.80 |
| NLRP3 inhibition | contributes_to | phenotype | 0.80 |
| HIF1A | activates | protein | 0.80 |
| Srt2104 | upregulates | drug | 0.80 |
| HIF1 | activates | protein | 0.80 |
| FOXO | activates | protein | 0.80 |
| APOPTOSIS | activates | gene | 0.80 |
| ischemia | regulates | process | 0.70 |
| PINK1 | regulates | gene | 0.70 |
| PINK1 | activates | gene | 0.70 |
| NIX | regulates | gene | 0.70 |
| MITOPHAGY | contributes_to | gene | 0.70 |
| ATG | regulates | gene | 0.70 |
| CAT | interacts_with | gene | 0.60 |
| OPTN | interacts_with | gene | 0.60 |
| DNM1L | interacts_with | gene | 0.60 |
| CANX | interacts_with | gene | 0.60 |
| LGALS3 | interacts_with | gene | 0.60 |
| CALCOCO2 | interacts_with | gene | 0.60 |
| G3BP1 | interacts_with | gene | 0.60 |
| PEX3 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| BCL2 | interacts_with | gene | 0.60 |
| LMNA | interacts_with | gene | 0.60 |
| STING1 | interacts_with | gene | 0.60 |
| TAX1BP1 | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| SNCAIP | interacts_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| ERN1 | interacts_with | gene | 0.60 |
| PARKIN | interacts_with | gene | 0.60 |
| FMR1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| FAM134B | interacts_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| EPAS1 | interacts_with | gene | 0.60 |
| MIRO1 | interacts_with | gene | 0.60 |
| CTSD | interacts_with | gene | 0.60 |
| RB1 | interacts_with | gene | 0.60 |
| EIF2AK3 | interacts_with | gene | 0.60 |
| PRKN | interacts_with | gene | 0.60 |
| BCL2L11 | interacts_with | gene | 0.60 |
| MUL1 | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.450
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||