Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRAMD1B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GRAMD1B |
| Aliases | Page for GRAMD1B Protein |
| Chromosome | 11q13.4 |
| Function | GRAMD1B (GRAM Domain Containing 1B, also known as VIPAR) is a 559-amino acid protein encoded by the GRAMD1B gene (NCBI Gene: 54550). |
| Subcellular Localization | primarily to the endoplasmic reticulum (ER) and endosomes, where it participates |
| Molecular Weight | 65 kDa |
| Amino Acids | 762 aa |
| Pathways | mTOR |
| GeneCards | GRAMD1B |
| Human Protein Atlas | GRAMD1B |
| Associated Diseases | Ovarian Cancer |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRAMD1B["GRAMD1B"]
Ovarian_Cancer["Ovarian Cancer"]
tumor_immune_cell_activity["tumor immune cell activity"]
GRAMD1B -->|"associated with"| Ovarian_Cancer
GRAMD1B -->|"modulates"| tumor_immune_cell_activity
style GRAMD1B fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#fff
style Ovarian_Cancer fill:#3e1a1a,stroke:#ef5350,stroke-width:2px,color:#fff
style tumor_immune_cell_activity fill:#1a1a2e,stroke:#888,stroke-width:2px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Ovarian Cancer | associated_with | disease | 0.85 |
| tumor immune cell activity | modulates | process | 0.75 |
| MAP1A | associated_with | gene | 0.60 |
| MYL9 | associated_with | gene | 0.60 |
| NFE2L3 | associated_with | gene | 0.60 |
| SIGLEC11 | associated_with | gene | 0.60 |
| SLC24A4 | associated_with | gene | 0.60 |
| SPINT1 | associated_with | gene | 0.60 |
| XPR1 | associated_with | gene | 0.60 |
| MAPT | translocates_to | gene | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| PI3K | regulates | gene | 0.60 |
| PI3K-AKT-mTOR signaling | participates_in | pathway | 0.60 |
| stem cells | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||