protein

NR2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

1Analyses

10Outgoing

5Incoming

0Experiments

1Debates

Summary

Page for NR2B (GluN2B) NMDA Receptor Subunit

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🔬 Protein Info

Gene Symbol	NR2B
Full Name	NR2B (GluN2B)
Aliases	GluN2B
Protein Family	Ionotropic glutamate receptor (NMDA) family
Protein Type	Receptor
Function	NR2B (GRIN2B) is a subunit of the NMDA glutamate receptor that modulates synaptic plasticity, learning, and memory
Primary Expression	the forebrain, where they mediate long-term potentiation
Subcellular Localization	Postsynaptic density,
Molecular Weight	180 kDa
Pathways	Epigenetic
UniProt ID	Q13691
GeneCards	NR2B
Human Protein Atlas	NR2B
Associated Diseases	excitotoxicity
Interactions	ABETA, CDK5
KG Connections	15 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: NR2B — AlphaFold Q13691 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NR2B["NR2B"]
    NR2B -->|"activates"| ALS["ALS"]
    NR2B -->|"regulates"| PSD95["PSD95"]
    NR2B -->|"regulates"| FOS["FOS"]
    NR2B -->|"regulates"| C_FOS["C-FOS"]
    NR2B -->|"regulates"| NPAS4["NPAS4"]
    NR2B -->|"regulates"| AND["AND"]
    NR2B -->|"regulates"| DLG4["DLG4"]
    NR2B -->|"regulates"| GRIN2B["GRIN2B"]
    GENES["GENES"] -->|"regulates"| NR2B
    NPAS4 -->|"regulates"| NR2B
    DLG4 -->|"regulates"| NR2B

Outgoing (10)

Target	Relation	Type	Str
excitotoxicity	causes	phenotype	0.70
ALS	activates	disease	0.65
FOS	regulates	gene	0.60
NPAS4	regulates	gene	0.60
DLG4	regulates	gene	0.60
GRIN2B	regulates	gene	0.60
C-FOS	regulates	gene	0.60
Epigenetic	activates	pathway	0.60
PSD95	regulates	gene	0.60
Neuron	expressed_in	cell_type	0.55

Incoming (5)

Source	Relation	Type	Str
CDK5	phosphorylates	gene	0.90
ABETA	activates	protein	0.80
GENES	regulates	gene	0.60
NPAS4	regulates	gene	0.50
DLG4	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The abstract claims Cdk5 activation is the primary cause of AD, contradicting th

closed · Rounds: 4 · Score: 0.50 · 2026-04-20

Related Research

Hypotheses and analyses mentioning NR2B in their description or question text

No additional research found