Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DLG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
DLG4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, co discussed. Associated with Neurodegeneration. Connected to 30 entities in the SciDEX knowledge graph.
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| Gene Symbol | DLG4 |
| Full Name | Discs Large Homolog 4 / PSD-95 |
| Aliases | DLG4/PSD-95 gene |
| Chromosome | 8p21.2 |
| Function | DLG4/PSD-95 performs critical synaptic functions[3] |
| Molecular Weight | 95 kDa |
| Amino Acids | 724 aa |
| Pathways | Dendritic Spine |
| UniProt ID | [P78352](https://www.uniprot.org/uniprot/P78352) |
| Ensembl ID | ENSG00000132587 |
| GeneCards | DLG4 |
| Human Protein Atlas | DLG4 |
| Synaptic scaffolding | Organizes the postsynaptic density by anchoring NMDA receptors, AMPA receptors, and other signaling proteins |
| Synaptic transmission | Regulates glutamate receptor trafficking and function at excitatory synapses |
| Synaptic plasticity | Essential for long-term potentiation (LTP) and long-term depression (LTD) induction |
| Associated Diseases | Aging, Autism, autism spectrum disorders, Tinnitus, Williams' syndrome |
| Interactions | ACHE, ANXIETY, ARC, ATM, BDNF, BRCA1 |
| KG Connections | 167 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
DLG4["<b>DLG4</b>"]
Acoustic_Stimulation_Response(["Acoustic Stimulation Response"])
DLG4 -->|"involved in"| Acoustic_Stimulation_Response
PARP1["PARP1"]
DLG4 -->|"associated with"| PARP1
SYN1["SYN1"]
DLG4 -->|"associated with"| SYN1
GRIN2B["GRIN2B"]
DLG4 -->|"associated with"| GRIN2B
Neurodegeneration{"Neurodegeneration"}
DLG4 -->|"interacts with"| Neurodegeneration
TNF["TNF"]
DLG4 -->|"co discussed"| TNF
NEURODEGENERATION["NEURODEGENERATION"]
DLG4 -->|"associated with"| NEURODEGENERATION
CASP3["CASP3"]
DLG4 -->|"interacts with"| CASP3
BDNF["BDNF"]
DLG4 -->|"associated with"| BDNF
NR3C1["NR3C1"]
DLG4 -->|"interacts with"| NR3C1
PVALB["PVALB"]
DLG4 -->|"associated with"| PVALB
DLG4 -->|"interacts with"| NEURODEGENERATION
BDNF -->|"associated with"| DLG4
APP["APP"]
APP -->|"co discussed"| DLG4
BDNF -->|"co discussed"| DLG4
CASP3 -->|"associated with"| DLG4
CASP3 -->|"interacts with"| DLG4
FKBP5["FKBP5"]
FKBP5 -->|"interacts with"| DLG4
PVALB -->|"associated with"| DLG4
NR3C1 -->|"interacts with"| DLG4
NEURODEGENERATION -->|"interacts with"| DLG4
TNF -->|"associated with"| DLG4
APP -->|"associated with"| DLG4
AND["AND"]
AND -->|"associated with"| DLG4
style DLG4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| synaptic transmission | involved_in | process | 0.80 |
| Acoustic Stimulation Response | involved_in | process | 0.75 |
| Acoustic Stimulation | involved_in | process | 0.75 |
| Aging | associated_with | disease | 0.65 |
| Schizophrenia | expressed_in | disease | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Autism | associated_with | disease | 0.65 |
| ANXIETY | inhibits | disease | 0.65 |
| Neurodegeneration | interacts_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Anxiety | activates | disease | 0.65 |
| Anxiety | expressed_in | disease | 0.65 |
| GRIN2B | associated_with | gene | 0.65 |
| PARP1 | associated_with | gene | 0.65 |
| SYN1 | associated_with | gene | 0.65 |
| TNF | co_discussed | gene | 0.60 |
| TNF | associated_with | entity | 0.60 |
| synaptic abnormalities | contributes_to | phenotype | 0.60 |
| Caspase | expressed_in | protein | 0.60 |
| DMSO | regulates | gene | 0.60 |
| cortex | expressed_in | brain_region | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| Neuron | interacts_with | cell_type | 0.60 |
| DEPRESSION | expressed_in | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| Alzheimer's disease | regulates | disease | 0.60 |
| Williams' syndrome | associated_with | disease | 0.60 |
| autism spectrum disorders | associated_with | disease | 0.60 |
| Synaptic Plasticity | expressed_in | pathway | 0.60 |
| Apoptosis | expressed_in | pathway | 0.60 |
| GABA | expressed_in | gene | 0.60 |
| Tinnitus | associated_with | disease | 0.60 |
| PSD95 | activates | gene | 0.60 |
| SYP | activates | gene | 0.60 |
| NEURON | expressed_in | gene | 0.60 |
| ANXIETY | expressed_in | gene | 0.60 |
| autism spectrum disorder | interacts_with | disease | 0.60 |
| GABA | biomarker_for | gene | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Dendritic Spine | regulates | pathway | 0.60 |
| amygdala | expressed_in | brain_region | 0.60 |
| GRIN2B | regulates | gene | 0.60 |
| IBA1 | regulates | gene | 0.60 |
| PPARA | regulates | gene | 0.60 |
| NEURODEGENERATION | associated_with | gene | 0.60 |
| NEURODEGENERATION | interacts_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Chlorogenic acid | upregulates | compound | 0.85 |
| Fisetin | upregulates | compound | 0.85 |
| BDNF | upregulates | gene | 0.80 |
| Transcranial near-infrared light | upregulates | compound | 0.80 |
| BRD4 | regulates | gene | 0.70 |
| BDNF | associated_with | gene | 0.65 |
| CORTEX | degrades | brain_region | 0.65 |
| APP | regulates | gene | 0.60 |
| BDNF | regulates | gene | 0.60 |
| BECN1 | regulates | gene | 0.60 |
| CD68 | regulates | gene | 0.60 |
| CREB1 | regulates | gene | 0.60 |
| DEPRESSION | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| ACHE | activates | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| ADAM10 | regulates | gene | 0.60 |
| AIF1 | regulates | gene | 0.60 |
| APOE | regulates | gene | 0.60 |
| NR2B | regulates | gene | 0.60 |
| PSD95 | regulates | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| NPAS4 | regulates | gene | 0.60 |
| NEURODEGENERATION | interacts_with | gene | 0.60 |
| FOS | regulates | gene | 0.60 |
| SATB2 | expressed_in | gene | 0.60 |
| GAD1 | expressed_in | gene | 0.60 |
| ANXIETY | co_discussed | gene | 0.60 |
| DEPRESSION | associated_with | gene | 0.60 |
| GENES | regulates | gene | 0.60 |
| C-FOS | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
| ANXIETY | expressed_in | gene | 0.60 |
| GABA | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| NEURON | expressed_in | gene | 0.60 |
| BDNF | co_discussed | gene | 0.60 |
| CASP3 | associated_with | gene | 0.60 |
| CASP3 | interacts_with | gene | 0.60 |
| FKBP5 | interacts_with | gene | 0.60 |
| PVALB | associated_with | gene | 0.60 |
| NR3C1 | interacts_with | gene | 0.60 |
| TNF | associated_with | gene | 0.60 |
| APP | associated_with | gene | 0.60 |
| APP | co_discussed | gene | 0.60 |
| BDNF | activates | gene | 0.55 |
| BRCA1 | activates | gene | 0.55 |
| BRD4 | activates | gene | 0.55 |
| CAMK2A | activates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914
neurodegeneration | 2026-04-03 | 37 hypotheses Top: 0.990
neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.757
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
closed · Rounds: 4 · Score: 0.95 · 2026-04-03