gene

DLG4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DLG4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

167Connections
0Hypotheses
3Analyses
50Outgoing
50Incoming
0Experiments
3Debates

Summary

DLG4 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, co discussed. Associated with Neurodegeneration. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolDLG4
Full NameDiscs Large Homolog 4 / PSD-95
AliasesDLG4/PSD-95 gene
Chromosome8p21.2
FunctionDLG4/PSD-95 performs critical synaptic functions[3]
Molecular Weight95 kDa
Amino Acids724 aa
PathwaysDendritic Spine
UniProt ID[P78352](https://www.uniprot.org/uniprot/P78352)
Ensembl IDENSG00000132587
GeneCardsDLG4
Human Protein AtlasDLG4
Synaptic scaffoldingOrganizes the postsynaptic density by anchoring NMDA receptors, AMPA receptors, and other signaling proteins
Synaptic transmissionRegulates glutamate receptor trafficking and function at excitatory synapses
Synaptic plasticityEssential for long-term potentiation (LTP) and long-term depression (LTD) induction
Associated DiseasesAging, Autism, autism spectrum disorders, Tinnitus, Williams' syndrome
InteractionsACHE, ANXIETY, ARC, ATM, BDNF, BRCA1
KG Connections167 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🧬 3D Structure: DLG4 — PDB 1BE9 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

DLG4 Gene - PSD-95

gene · 735 words

PSD-95 Protein (DLG4)

protein · 1607 words

DLG4 Gene

gene · 1025 words

DLG4 Protein

protein · 553 words

Pathway Diagram

graph TD
    DLG4["<b>DLG4</b>"]
    Acoustic_Stimulation_Response(["Acoustic Stimulation Response"])
    DLG4 -->|"involved in"| Acoustic_Stimulation_Response
    PARP1["PARP1"]
    DLG4 -->|"associated with"| PARP1
    SYN1["SYN1"]
    DLG4 -->|"associated with"| SYN1
    GRIN2B["GRIN2B"]
    DLG4 -->|"associated with"| GRIN2B
    Neurodegeneration{"Neurodegeneration"}
    DLG4 -->|"interacts with"| Neurodegeneration
    TNF["TNF"]
    DLG4 -->|"co discussed"| TNF
    NEURODEGENERATION["NEURODEGENERATION"]
    DLG4 -->|"associated with"| NEURODEGENERATION
    CASP3["CASP3"]
    DLG4 -->|"interacts with"| CASP3
    BDNF["BDNF"]
    DLG4 -->|"associated with"| BDNF
    NR3C1["NR3C1"]
    DLG4 -->|"interacts with"| NR3C1
    PVALB["PVALB"]
    DLG4 -->|"associated with"| PVALB
    DLG4 -->|"interacts with"| NEURODEGENERATION
    BDNF -->|"associated with"| DLG4
    APP["APP"]
    APP -->|"co discussed"| DLG4
    BDNF -->|"co discussed"| DLG4
    CASP3 -->|"associated with"| DLG4
    CASP3 -->|"interacts with"| DLG4
    FKBP5["FKBP5"]
    FKBP5 -->|"interacts with"| DLG4
    PVALB -->|"associated with"| DLG4
    NR3C1 -->|"interacts with"| DLG4
    NEURODEGENERATION -->|"interacts with"| DLG4
    TNF -->|"associated with"| DLG4
    APP -->|"associated with"| DLG4
    AND["AND"]
    AND -->|"associated with"| DLG4
    style DLG4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (103)

TargetRelationTypeStr
synaptic transmissioninvolved_inprocess0.80
Acoustic Stimulation Responseinvolved_inprocess0.75
Acoustic Stimulationinvolved_inprocess0.75
Agingassociated_withdisease0.65
Schizophreniaexpressed_indisease0.65

Incoming (64)

SourceRelationTypeStr
Chlorogenic acidupregulatescompound0.85
Fisetinupregulatescompound0.85
BDNFupregulatesgene0.80
Transcranial near-infrared lightupregulatescompound0.80
BRD4regulatesgene0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 9 hypotheses Top: 0.914

Gene expression changes in aging mouse brain predicting neurodegenerative vulner

neurodegeneration | 2026-04-03 | 37 hypotheses Top: 0.990

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.757

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Epigenetic reprogramming in aging neurons

closed · Rounds: 4 · Score: 0.95 · 2026-04-10

What gene expression changes in the aging mouse brain predict neurodegenerative

closed · Rounds: 4 · Score: 0.95 · 2026-04-03

Evaluate the potential of CRISPR/Cas9 and related gene editing technologies for

closed · Rounds: 4 · Score: 0.95 · 2026-04-03