gene

NPAS4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NPAS4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

0Analyses

39Outgoing

33Incoming

Summary

Page for NPAS4 Gene

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🧬 Gene Info

Gene Symbol	NPAS4
Full Name	Neuronal PAS domain protein 4
Chromosome	19q13.3
Protein Family	bHLH-PAS transcription factor family
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	102 kDa
Amino Acids	892 aa
Exons	9
Pathways	Autophagy, Notch
GeneCards	NPAS4
Human Protein Atlas	NPAS4
bHLH domain	N-terminal (50-100 aa)
PAS-A domain	(150-250 aa)
PAS-B domain	(300-400 aa)
Associated Diseases	neurodegeneration
Interactions	STAT3, HDAC3, FOXP1, WAS, C-FOS, CHIP
KG Connections	72 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NPAS4["<b>NPAS4</b>"]
    Alzheimer{"Alzheimer"}
    NPAS4 -->|"regulates"| Alzheimer
    Ms{"Ms"}
    NPAS4 -->|"regulates"| Ms
    APP["APP"]
    NPAS4 -->|"regulates"| APP
    Notch(["Notch"])
    NPAS4 -->|"regulates"| Notch
    neurodegeneration["neurodegeneration"]
    NPAS4 -->|"implicated in"| neurodegeneration
    APLP2["APLP2"]
    APLP2 -->|"regulates"| NPAS4
    APLP1["APLP1"]
    APLP1 -->|"regulates"| NPAS4
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"regulates"| NPAS4
    style NPAS4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (39)

Target	Relation	Type	Str
Alzheimer	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	activates	disease	0.65
Inflammation	regulates	disease	0.65
APP	regulates	gene	0.60
STAT3	activates	gene	0.60
HDAC3	activates	gene	0.60
BDNF	expressed_in	gene	0.60
FOXP1	activates	gene	0.60
HDAC3	regulates	gene	0.60
DLG4	regulates	gene	0.60
GRIN2B	regulates	gene	0.60
Notch	regulates	pathway	0.60
C-FOS	activates	gene	0.60
Neuron	activates	cell_type	0.60
Autophagy	regulates	pathway	0.60
Neuron	regulates	cell_type	0.60
C-FOS	regulates	gene	0.60
Epigenetic	activates	pathway	0.60
AND	expressed_in	gene	0.60
AND	regulates	gene	0.60
Bdnf	expressed_in	protein	0.60
AUTOPHAGY	regulates	gene	0.60
Ras	activates	protein	0.60
App	inhibits	protein	0.60
Neuron	expressed_in	cell_type	0.55
HDAC3	inhibits	gene	0.50
NR2B	regulates	protein	0.50
PSD95	regulates	gene	0.50
WAS	activates	protein	0.50
CHIP	activates	protein	0.50
NEURONS	activates	concept	0.50
BRAIN INJURY	activates	concept	0.50
Neuroprotection	activates	process	0.50
CENTRAL NERVOUS SYSTEM	regulates	concept	0.50
inflammation	inhibits	pathway	0.50
BRAIN INJURY	inhibits	concept	0.50

Incoming (33)

Source	Relation	Type	Str
BDNF	is_target_of	gene	0.80
APLP2	regulates	gene	0.60
APLP1	regulates	gene	0.60
HDAC3	inhibits	protein	0.60
BDNF	expressed_in	gene	0.60
STAT3	activates	gene	0.60
FOS	activates	gene	0.60
ARNT	regulates	gene	0.60
NR2B	regulates	gene	0.60
PSD95	regulates	gene	0.60
FOS	regulates	gene	0.60
HDAC3	regulates	gene	0.60
FOXP1	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
GENES	regulates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
C-FOS	activates	gene	0.60
PER	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
BRAIN INJURY	activates	gene	0.60
C-FOS	regulates	gene	0.60
ARNT	activates	gene	0.50
HDAC3	activates	gene	0.50
BDNF	regulates	gene	0.50
BDNF	activates	gene	0.50
BDNF	associated_with	gene	0.50
AUTOPHAGY	activates	gene	0.50
GENES	co_discussed	gene	0.50
NEURON	co_discussed	gene	0.50
Autophagy	inhibits	process	0.50
BDNF	co_mentioned	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NPAS4

Understanding Entity Pages

Summary

Wiki Pages (14)

NPAS4 Gene

Orexin Neurons

rest-protein

mef2c

KCNIP3

Neurotrophic Factor Signaling Decline in Neurodegeneration

ARNT2 - Aryl Hydrocarbon Receptor Nuclear Translocator 2

SNAP47 Gene — Synaptosome-Associated Protein 47

KAT2A (Lysine Acetyltransferase 2A)

Bed Nucleus of the Stria Terminalis (BNST) Neurons

NR2B (GluN2B) NMDA Receptor Subunit

NPAS4 Protein