protein

NR4A1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NR4A1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

Nur77 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	NR4A1PROTEIN
Chromosome	12p13.31
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	64 kDa
Amino Acids	598 aa
Exons	7
GeneCards	NR4A1PROTEIN
Human Protein Atlas	NR4A1PROTEIN
DNA Binding	Binds to Nur response elements (NurRE) and NGFI-B response elements (NBRE)
Target Genes	Regulates genes involved in:
Coactivator Recruitment	Utilises p300/CBP for transcriptional activation
Calcium signaling	CaMK and calcineurin pathways
cAMP/PKA	Protein kinase A activation
MAPK cascades	ERK, JNK, and p38 pathways
Associated Diseases	Aging, Als, Inflammation, Ms, Neurodegeneration
Interactions	AKT, ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS, App, ARC
KG Connections	125 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Nur77 Protein

protein · 810 words

→

Pathway Diagram

graph TD
    NR4A1PROTEIN["NR4A1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    NR4A1PROTEIN -->|"implicated_in"| neurodegeneration
    style NR4A1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NR4A1PROTEIN in their description or question text

No additional research found