gene

OTUD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OTUD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

0Hypotheses

0Analyses

8Outgoing

1Incoming

Summary

Gene profile: OTUD4 — OTU Domain Containing 4, a deubiquitinase involved in protein quality control, DNA repair, and stress responses in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	OTUD4
Full Name	OTU Deubiquitinase 4
Chromosome	4q31.3
Primary Expression	both neurons and glia:
Molecular Weight	113 kDa
Amino Acids	032 aa
Pathways	Mapk
Ensembl ID	ENSG00000145362
GeneCards	OTUD4
Human Protein Atlas	OTUD4
K48-linked chains	Targets proteins for proteasomal degradation
K63-linked chains	Modulates signaling cascades, protein localization, and complex formation
Associated Diseases	Cancer
Interactions	FGFR1, CDK1
KG Connections	9 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    OTUD4["<b>OTUD4</b>"]
    Ms{"Ms"}
    OTUD4 -->|"activates"| Ms
    Cancer{"Cancer"}
    OTUD4 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    OTUD4 -->|"activates"| Tumor
    Glioblastoma{"Glioblastoma"}
    OTUD4 -->|"activates"| Glioblastoma
    CANCER["CANCER"]
    OTUD4 -->|"associated with"| CANCER
    GBM["GBM"]
    OTUD4 -->|"therapeutic target"| GBM
    FGFR1["FGFR1"]
    OTUD4 -->|"activates"| FGFR1
    Mapk(["Mapk"])
    OTUD4 -->|"activates"| Mapk
    neurodegeneration["neurodegeneration"]
    OTUD4 -->|"implicated in"| neurodegeneration
    CDK1["CDK1"]
    CDK1 -->|"activates"| OTUD4
    style OTUD4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (8)

Target	Relation	Type	Str
Ms	activates	disease	0.65
Cancer	associated_with	disease	0.65
Tumor	activates	disease	0.65
Glioblastoma	activates	disease	0.65
GBM	therapeutic_target	gene	0.60
FGFR1	activates	gene	0.60
CANCER	associated_with	gene	0.60
Mapk	activates	pathway	0.60

Incoming (1)

Source	Relation	Type	Str
CDK1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found