concept

PAD4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PAD4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

0Hypotheses

0Analyses

26Outgoing

3Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PAD4
Key Genes/Proteins	AND
Related Diseases	Tubulointerstitial Injury, Diabetic Kidney Disease, Acute Lung Injury

Wiki Pages (1)

Knowledge base pages for this entity

NETosis in Neurodegeneration

mechanism · 976 words

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Pathway Diagram

graph TD
    PAD4["PAD4"]
    PAD4 -->|"promotes"| Macrophage_Migration["Macrophage Migration"]
    PAD4 -->|"involved_in"| Neutrophil_Extracellular_Trap_["Neutrophil Extracellular Trap Formation"]
    PAD4 -->|"activates"| NETs["NETs"]
    PAD4 -->|"contributes to"| Diabetic_Kidney_Disease["Diabetic Kidney Disease"]
    PAD4 -->|"promotes"| Tubulointerstitial_Injury["Tubulointerstitial Injury"]
    PAD4 -->|"promotes"| Nets["Nets"]
    CMKLR1["CMKLR1"] -->|"activates"| PAD4
    AND["AND"] -->|"activates"| PAD4
    IL_18["IL-18"] -->|"inhibits"| PAD4

Outgoing (26)

Target	Relation	Type	Str
Macrophage Migration	associated_with	process	0.95
Macrophage Migration	promotes	process	0.95
NETs	drives	process	0.95
Tubulointerstitial Injury	associated_with	phenotype	0.90
NETs	activates	process	0.90
Tubulointerstitial Injury	promotes	phenotype	0.90
Macrophage	regulates	cell_type	0.90
Diabetic Kidney Disease	involved_in	disease	0.88
NETs	regulates	process	0.88
Nets	promotes	process	0.85
Nets	involved_in	process	0.85
Macrophages	regulates	cell_type	0.82
macrophage	associated_with	cell_type	0.80
Acute Lung Injury	involved_in	disease	0.80
AND	activates	gene	0.60
CMKLR1	activates	gene	0.60
Macrophage	activates	cell_type	0.60
AND	inhibits	gene	0.60
IFN	inhibits	gene	0.60
CX43	inhibits	gene	0.60
IFN-Γ	inhibits	gene	0.60
Neutrophil	inhibits	cell_type	0.60
Il-1	inhibits	protein	0.60
Il-18	inhibits	protein	0.60
macrophages	expressed_in	cell_type	0.60
Macrophage	expressed_in	cell_type	0.55

Incoming (3)

Source	Relation	Type	Str
CMKLR1	activates	gene	0.60
AND	activates	gene	0.60
IL-18	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found