concept

MACROPHAGES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MACROPHAGES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1862Connections

4Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

Summary

MACROPHAGES is a concept in neurodegeneration research. Key relationships include: co discussed, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ATHEROSCLEROSIS. Connected to 214 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MACROPHAGES
Key Genes/Proteins	ABCA1, ABCA7, ACHE, acvr1, ADAM8, AIM2
Related Diseases	ACETYLCHOLINE, aging, ALZHEIMER, ALZHEIMER'S, Alzheimer'S Disease

Pathway Diagram

graph TD
    MACROPHAGES["MACROPHAGES"]
    MACROPHAGES -->|"mediates"| Tubulointerstitial_Injury["Tubulointerstitial Injury"]
    MACROPHAGES -->|"regulates"| INFLAMMATION_1["INFLAMMATION_1"]
    MACROPHAGES -->|"activates"| CYTOKINES["CYTOKINES"]
    MACROPHAGES -->|"regulates"| neuroinflammatory_responses["neuroinflammatory responses"]
    MACROPHAGES -->|"activates"| glioblastoma["glioblastoma"]
    MACROPHAGES -->|"causes"| AXONAL_LOSS["AXONAL_LOSS"]
    MACROPHAGES -->|"activates"| PRO_INFLAMMATORY_CYTOKINES["PRO_INFLAMMATORY_CYTOKINES"]
    MACROPHAGES -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    MACROPHAGES -->|"activates"| FREE_RADICALS["FREE_RADICALS"]
    MACROPHAGES -->|"activates"| GLUTAMATE["GLUTAMATE"]
    PAD4["PAD4"] -->|"regulates"| MACROPHAGES
    PIEZO1["PIEZO1"] -->|"expressed in"| MACROPHAGES
    ADAM8["ADAM8"] -->|"expressed in"| MACROPHAGES
    C1Q["C1Q"] -->|"expressed in"| MACROPHAGES
    autophagy["autophagy"] -->|"regulates"| MACROPHAGES
    LOX["LOX"] -->|"expressed in"| MACROPHAGES
    itaconate["itaconate"] -->|"regulates"| MACROPHAGES
    LPS["LPS"] -->|"activates"| MACROPHAGES
    miR_369_3p["miR_369_3p"] -->|"expressed in"| MACROPHAGES
    SMC["SMC"] -->|"activates"| MACROPHAGES

Outgoing (556)

Target	Relation	Type	Str
MICROGLIA	interacts_with	cell_type	0.95
NF-KB	activates	gene	0.95
Efferocytosis	involved_in	process	0.95
Aβ42 Fibrils	associated_with	compound	0.95
MONOCYTES	inhibits	cell_type	0.95
Cardiovascular Disease	involved_in	disease	0.95
Phagocytosis	involved_in	process	0.95
AMYLOID-BETA 42 FIBRILS	produces	protein	0.95
Aβ42	associated_with	protein	0.95
Alzheimer Disease	contributes_to	disease	0.95
Bacteria	associated_with	organism	0.95
MICROGLIA	associated_with	cell_type	0.95
neuroinflammation	modulates	process	0.90
Liver Homeostasis	associated_with	process	0.90
Periodontitis	involved_in	disease	0.90
Systemic Inflammation	mediates	process	0.90
LGALS9	expressed_in	protein	0.90
phagocytosis	activates	process	0.90
Inflammation	mediates	process	0.90
LC3-associated phagocytosis	expressed_in	process	0.90
Acute Ischemic Stroke	contributes_to	disease	0.90
Atherosclerosis	contributes_to	disease	0.90
Plaque Inflammation	mediates	process	0.90
HMGB1	produces	protein	0.89
Lipid Droplet Accumulation	associated_with	phenotype	0.89
Neutrophil Clearance	mediates	process	0.88
Tubulointerstitial Injury	contributes_to	phenotype	0.88
systemic inflammation	mediates	process	0.88
pro-inflammatory signaling	activates	pathway	0.85
lesion formation	drives	process	0.85
Myocardial Fibrosis	contributes_to	phenotype	0.85
Axonal Loss	contributes_to	process	0.85
Salivary Gland Damage	contributes_to	phenotype	0.85
Pro-Inflammatory Signals	associated_with	process	0.85
Plaque Inflammation	promotes	process	0.85
Pro-inflammatory Signals	mediates	process	0.85
Microglia	correlates_with	cell_type	0.85
Nerve Degeneration	modulates	process	0.85
Atherosclerosis	involved_in	disease	0.85
Brain Inflammation	mediates	process	0.85
Iron Recycling	involved_in	process	0.85
Tubulointerstitial Injury	mediates	phenotype	0.85
Autophagy	expressed_in	process	0.85
Cell Communication	involved_in	process	0.80
Glutamate	product_of	compound	0.80
NEUTROPHILS	interacts_with	cell_type	0.80
STEM CELLS	activates	cell_type	0.80
Multiple Sclerosis	contributes_to	disease	0.80
Sensory axon loss	protects_against	phenotype	0.80
Vascular Injury	mediates	process	0.80

Incoming (1306)

Source	Relation	Type	Str
FIBROSIS	activates	disease	0.95
TREM2	expressed_in	gene	0.95
ABCA7	expressed_in	protein	0.95
ANXA1	expressed_in	protein	0.95
LOX	expressed_in	protein	0.95
NF-kB signaling	active_in	pathway	0.90
NLRP3	activates	gene	0.90
aging	affects	disease	0.90
ferroptosis	active_in	pathway	0.90
CCR2	expressed_in	gene	0.90
neuroinflammation	affects	disease	0.90
Alzheimer's disease	affects	disease	0.90
stroke	affects	disease	0.90
PI3K-AKT-mTOR signaling	active_in	pathway	0.90
DCLK1	expressed_in	gene	0.90
unfolded protein response	active_in	pathway	0.90
39874259	show increased infiltration and expression of	paper	0.90
TNF	expressed_in	gene	0.90
neurodegeneration	affects	disease	0.90
glioblastoma	affects	disease	0.90
pyroptosis	active_in	pathway	0.90
FPR1	expressed_in	receptor	0.90
spinal muscular atrophy	affects	disease	0.90
IL-4-STAT6 pathway	protects_against	pathway	0.90
FK866	suppresses	drug	0.85
Malate	expressed_in	compound	0.85
α-Synuclein	expressed_in	protein	0.85
SNCA	expressed_in	protein	0.85
PAD4	regulates	gene	0.82
CR1	expressed_in	gene	0.80
GBM	inhibits	gene	0.80
AKT	activates	gene	0.80
NLRP3	causes	gene	0.80
THBS1	expressed_in	gene	0.80
PI3K	regulates	gene	0.80
CD33	expressed_in	gene	0.80
diabetes	affects	disease	0.80
RNA	associated_with	gene	0.80
CCL2	expressed_in	gene	0.80
TNF	inhibits	gene	0.80
lipid metabolism	active_in	pathway	0.80
ISCHEMIA	activates	disease	0.80
STING	activates	gene	0.80
TNF	activates	gene	0.80
ATHEROSCLEROSIS	activates	disease	0.80
RNA	inhibits	gene	0.80
RNA	activates	gene	0.80
STING	regulates	gene	0.80
TGF-beta signaling	active_in	pathway	0.80
cGAS-STING	active_in	pathway	0.80

Targeting Hypotheses (4)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Mutant-dependent amplification is context-dependent and stro	0.740	neurodegeneration	Do pathogenic LRRK2 mutations amplify vo
C1Q-Triggered NLRP3 Inflammasome Assembly in Plaque Macropha	0.631	neuroinflammation	What are the specific molecular mechanis
CD36 Acts as Primary Aβ Oligomer Sensor on Perivascular Macr	0.535	neurodegeneration	How do perivascular cells specifically r
TREM2 on Perivascular Macrophages Senses Aβ and Drives SPP1	0.496	neurodegeneration	How do perivascular cells specifically r

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning MACROPHAGES in their description or question text

No additional research found