concept

MACROPHAGES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MACROPHAGES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1875Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

MACROPHAGES is a concept in neurodegeneration research. Key relationships include: co discussed, activates, regulates. Associated with ALZHEIMER, ALZHEIMER'S, ATHEROSCLEROSIS. Connected to 214 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	MACROPHAGES
Key Genes/Proteins	NF-KB, IL-10, CYTOKINES, PIEZO1, C1Q
Related Diseases	FIBROSIS, ATHEROSCLEROSIS, ISCHEMIA, INFLAMMATION_1

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MACROPHAGES["MACROPHAGES"]
    MACROPHAGES -->|"mediates"| Tubulointerstitial_Injury["Tubulointerstitial Injury"]
    MACROPHAGES -->|"regulates"| INFLAMMATION_1["INFLAMMATION_1"]
    MACROPHAGES -->|"activates"| CYTOKINES["CYTOKINES"]
    MACROPHAGES -->|"regulates"| neuroinflammatory_responses["neuroinflammatory responses"]
    MACROPHAGES -->|"activates"| glioblastoma["glioblastoma"]
    MACROPHAGES -->|"causes"| AXONAL_LOSS["AXONAL_LOSS"]
    MACROPHAGES -->|"activates"| PRO_INFLAMMATORY_CYTOKINES["PRO_INFLAMMATORY_CYTOKINES"]
    MACROPHAGES -->|"contributes to"| NEURODEGENERATION["NEURODEGENERATION"]
    MACROPHAGES -->|"activates"| FREE_RADICALS["FREE_RADICALS"]
    MACROPHAGES -->|"activates"| GLUTAMATE["GLUTAMATE"]
    PAD4["PAD4"] -->|"regulates"| MACROPHAGES
    PIEZO1["PIEZO1"] -->|"expressed in"| MACROPHAGES
    ADAM8["ADAM8"] -->|"expressed in"| MACROPHAGES
    C1Q["C1Q"] -->|"expressed in"| MACROPHAGES
    autophagy["autophagy"] -->|"regulates"| MACROPHAGES
    LOX["LOX"] -->|"expressed in"| MACROPHAGES
    itaconate["itaconate"] -->|"regulates"| MACROPHAGES
    LPS["LPS"] -->|"activates"| MACROPHAGES
    miR_369_3p["miR_369_3p"] -->|"expressed in"| MACROPHAGES
    SMC["SMC"] -->|"activates"| MACROPHAGES

Outgoing (550)

Target	Relation	Type	Str
MICROGLIA	interacts_with	cell_type	0.95
NF-KB	activates	gene	0.95
MICROGLIA	implicated_in	cell_type	0.95
MONOCYTES	inhibits	cell_type	0.95
Nerve Degeneration	modulates	process	0.85
NEUTROPHILS	interacts_with	cell_type	0.80
STEM CELLS	activates	cell_type	0.80
INFLAMMATION_1	regulates	phenotype	0.72
CYTOKINES	activates	protein	0.72
CXCL8	interacts_with	gene	0.70
OXIDATIVE STRESS	causes	phenotype	0.70
CASP1	inhibits	gene	0.70
MMP9	produces	gene	0.70
CHOLESTEROL	inhibits	phenotype	0.70
CYTOKINES	treats	phenotype	0.70
NEURODEGENERATION	regulates	disease	0.65
NEUTROPHIL	increases	cell_type	0.65
NEURON	accumulates_in	cell_type	0.65
MTOR	interacts_with	gene	0.65
NEURON	protects_against	cell_type	0.65
NEURONS	protects_against	cell_type	0.65
UBIQUITIN	activates	gene	0.65
NRF2	activates	gene	0.65
P62	activates	gene	0.65
PI3K	activates	gene	0.65
PI3K	promotes	gene	0.65
MONOCYTE	interacts_with	cell_type	0.65
MONOCYTES	interacts_with	cell_type	0.65
MONOCYTE	sensitizes_to	cell_type	0.65
MONOCYTES	sensitizes_to	cell_type	0.65
NFKB	associated_with	gene	0.65
MONOCYTE	causes	cell_type	0.65
MICROGLIA	reduces	cell_type	0.65
MICROGLIA	therapeutic_target	cell_type	0.65
ROS	activates	protein	0.65
NEUROINFLAMMATION	implicated_in	process	0.65
NEUTROPHILS	activates	cell_type	0.65
MONOCYTES	causes	cell_type	0.65
PHAGOCYTOSIS	causes	phenotype	0.65
INFLAMMATION	targets	phenotype	0.65
AKT	causes	gene	0.65
STAT3	produces	gene	0.65
MYELOID CELLS	causes	cell_type	0.65
NASH	activates	disease	0.65
WALLERIAN DEGENERATION	interacts_with	phenotype	0.65
WALLERIAN DEGENERATION	produces	phenotype	0.65
WHITE MATTER	causes	brain_region	0.65
SEPSIS	causes	disease	0.65
ABCA1	inhibits	gene	0.65
ABCA1	activates	gene	0.65

Incoming (1325)

Source	Relation	Type	Str
FIBROSIS	activates	disease	0.95
ATHEROSCLEROSIS	activates	disease	0.80
ISCHEMIA	activates	disease	0.80
IL-10	activates	gene	0.80
PIEZO1	expressed_in	protein	0.72
C1Q	expressed_in	protein	0.72
HK2	exacerbates	gene	0.70
PCSK9	activates	gene	0.70
SQSTM1	regulates	gene	0.70
DEXAMETHASONE	regulates	drug	0.70
CD80	activates	gene	0.70
B CELLS	treats	cell_type	0.70
ACETYLCHOLINE	activates	phenotype	0.70
CSF1R	activates	gene	0.65
CSF1R	regulates	gene	0.65
CANCER	treats	disease	0.65
GLIOBLASTOMA	treats	disease	0.65
ATHEROSCLEROSIS	promotes	disease	0.65
ATHEROSCLEROSIS	associated_with	disease	0.65
ATHEROSCLEROSIS	regulates	disease	0.65
LC3	associated_with	gene	0.65
LRRK2	inhibits	gene	0.65
MACROPHAGE	sensitizes_to	cell_type	0.65
ALZHEIMER	associated_with	disease	0.65
ALZHEIMER'S	associated_with	disease	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.65
GLIOMA	promotes	disease	0.65
AKT	promotes	gene	0.65
ISCHEMIC	targets	disease	0.65
MACROPHAGE	accumulates_in	cell_type	0.65
APOE	expressed_in	gene	0.65
MACROPHAGE	increases	cell_type	0.65
MACROPHAGE	reduces	cell_type	0.65
CX3CR1	inhibits	gene	0.65
ATHEROSCLEROSIS	processes	disease	0.65
ISCHEMIA	contributes_to	disease	0.65
FERROPTOSIS	activates	process	0.65
CANCER	associated_with	disease	0.65
ATHEROSCLEROSIS	implicated_in	disease	0.65
FIBROSIS	regulates	disease	0.65
ENDOTHELIAL CELLS	regulates	cell_type	0.65
FIBROBLASTS	interacts_with	cell_type	0.65
MITOCHONDRIAL DYSFUNCTION	treats	phenotype	0.65
NLRP3 INFLAMMASOME	treats	pathway	0.65
NLRP3	targets	gene	0.65
MONOCYTES	produces	cell_type	0.65
GLYCOLYSIS	exacerbates	phenotype	0.65
EXOSOME	regulates	organelle	0.65
MYELOID CELLS	interacts_with	cell_type	0.65
NEUROINFLAMMATION	treats	phenotype	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How do perivascular cells specifically recognize and respond to amyloid-β to upr

neurodegeneration | 2026-04-06 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MACROPHAGES

Understanding Entity Pages

Summary

Wiki Pages (20)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Atypical Parkinsonism

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

CLCN10 — Chloride Voltage-Gated Channel 10

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

nlrc5-protein

Niemann-Pick Disease Type C (NPC)

Excitotoxicity in Neurodegeneration

Curcumin for Neurodegeneration

Microglial Senescence Pathway in Neurodegeneration

Multiple Sclerosis (MS)

gba