cell_type

Neutrophil

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Neutrophil: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

430Connections

0Hypotheses

1Analyses

7Outgoing

50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info

Cell Type	Neutrophil
Key Markers	GFAP, CD68, IL-1, IL-6, NRF2, HO-1, PPAR, FERROPTOSIS
Key Pathways	IL17, Nf-Κb, Calcium Signaling, Phagocytosis, Epigenetic
Associated Diseases	COPD Lung Tissue, Skeletal Muscle Inflammation, Spinal Cord Injury, Pyroptosis, Ferroptosis, Fibrosis
Linked Hypotheses	82 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Neutrophil["Neutrophil"] -->|"regulates"| COPD_Lung_Tissue["COPD Lung Tissue"]
    style COPD_Lung_Tissue fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Neutrophil["Neutrophil"] -->|"expressed in"| Spinal_Cord["Spinal Cord"]
    style Spinal_Cord fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Neutrophil["Neutrophil"] -->|"expressed in"| Thalamus["Thalamus"]
    style Thalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Neutrophil["Neutrophil"] -->|"expressed in"| Hypothalamus["Hypothalamus"]
    style Hypothalamus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Neutrophil["Neutrophil"] -->|"expressed in"| Brainstem["Brainstem"]
    style Brainstem fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Neutrophil["Neutrophil"] -->|"expressed in"| Cortex["Cortex"]
    style Cortex fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    GFAP["GFAP"] -.->|"inhibits"| Neutrophil["Neutrophil"]
    style GFAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CD68["CD68"] -.->|"inhibits"| Neutrophil["Neutrophil"]
    style CD68 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_1["IL-1"] -.->|"inhibits"| Neutrophil["Neutrophil"]
    style IL_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_6["IL-6"] -.->|"inhibits"| Neutrophil["Neutrophil"]
    style IL_6 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    NRF2["NRF2"] -->|"therapeutic target"| Neutrophil["Neutrophil"]
    style NRF2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Neutrophil fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (53)

Target	Relation	Type	Str
COPD Lung Tissue	upregulates	phenotype	0.88
Skeletal Muscle Inflammation	mediates	disease	0.85
Spinal Cord	expressed_in	brain_region	0.50
Thalamus	expressed_in	brain_region	0.50
Hypothalamus	expressed_in	brain_region	0.50
Brainstem	expressed_in	brain_region	0.50
Cortex	expressed_in	brain_region	0.50

Incoming (377)

Source	Relation	Type	Str
IL17	expressed_in	pathway	0.90
Anti-Il-17 Antibody	suppresses	drug	0.75
GFAP	inhibits	gene	0.60
CD68	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
NRF2	therapeutic_target	gene	0.60
HO-1	therapeutic_target	gene	0.60
PPAR	therapeutic_target	gene	0.60
FERROPTOSIS	regulates	gene	0.60
GPX4/SLC7A11	therapeutic_target	gene	0.60
ACSL4	therapeutic_target	gene	0.60
PYROPTOSIS	therapeutic_target	gene	0.60
BANG	activates	gene	0.60
GPR37	activates	gene	0.60
MICROGLIA	activates	gene	0.60
CYTOKINES	activates	gene	0.60
PHAGOCYTOSIS	activates	gene	0.60
SIRT6	associated_with	gene	0.60
RNA	regulates	gene	0.60
HNRNPA2B1	regulates	gene	0.60
JUN	inhibits	gene	0.60
FERROPTOSIS	inhibits	gene	0.60
ROS	activates	gene	0.60
DNA	activates	gene	0.60
EXERCISE	activates	gene	0.60
STAT1	regulates	gene	0.60
P38	regulates	gene	0.60
EPO	regulates	gene	0.60
ERK	regulates	gene	0.60
EPOR	regulates	gene	0.60
CXCL10	regulates	gene	0.60
ISG15	regulates	gene	0.60
LGALS9	regulates	gene	0.60
TLR4	regulates	gene	0.60
CSF2	regulates	gene	0.60
CSF2RA	regulates	gene	0.60
MAPK	therapeutic_target	gene	0.60
BCL-2	regulates	gene	0.60
TLR9	inhibits	gene	0.60
CYTOKINES	inhibits	gene	0.60
TLR4	inhibits	gene	0.60
TLR	inhibits	gene	0.60
CRH	regulates	gene	0.60
CXCL1	associated_with	gene	0.60
IL-17	activates	gene	0.60
MMP9	associated_with	gene	0.60
IL1B	associated_with	gene	0.60
TNF	activates	gene	0.60
JUN	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Systemic immune profiling and peripheral immune contributions to neurodegenerati

neurodegeneration | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Neutrophil

Understanding Entity Pages

Wiki Pages (20)

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

neuroinflammation

Astrocyte Reactivity Mechanism

omega-3-fatty-acids-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Multiple Sclerosis (MS)

NF-kB Signaling Pathway in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

MDS 2026 — Fluid Biomarker Advances in Neurodegeneration

Neuroinflammation in Amyotrophic Lateral Sclerosis

Blood-Brain Barrier Breakdown in Neurodegeneration

Neuroinflammation in Parkinson's Disease

cGAS-STING Signaling in Parkinson's Disease

SERPINA3 Gene — Alpha-1 Antichymotrypsin in Neurodegeneration

Reactive Oxygen Species (ROS) Pathway

Neuromyelitis Optica Spectrum Disorder (NMOSD)

Flotillin-1 Protein

IL32

Spinal Cord Injury