protein

IL-18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL-18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

455Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

Page for IL-18 Protein

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🔬 Protein Info

Gene Symbol	IL
Full Name	18 - Interleukin-18
Chromosome	11q22.2.
Function	Interleukin-1 beta (IL-1β) is a potent pro-inflammatory cytokine that plays a central role in the innate immune response and neuroinflammation.
GeneCards	IL
Human Protein Atlas	IL
Pro-inflammatory cytokines	TNF-α, IL-1β
Oxidative stress	ROS, mitochondrial dysfunction
Elevated levels	IL-18 is significantly elevated in CSF and plasma of AD patients compared to healthy controls
Disease correlation	Levels correlate with cognitive decline measured by MMSE and CDR
Pathology association	Associated with amyloid-β plaque deposition and tau hyperphosphorylation
Conversion prediction	Elevated IL-18 predicts conversion from mild cognitive impairment (MCI) to AD
Mechanistic role	Drives neuroinflammation and synaptic dysfunction
Therapeutic target	IL-18 neutralization reduces pathology in AD mouse models
Associated Diseases	CRC
KG Connections	1 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    IL_18(["IL-18"])
    NLRP3["NLRP3"]
    NLRP3_Inflammasome_Activation["NLRP3 Inflammasome Activation"]
    NLRP3_Inflammasome["NLRP3 Inflammasome"]
    Status_Epilepticus["Status Epilepticus"]
    INFLAMMASOME["INFLAMMASOME"]
    Neurodegeneration["Neurodegeneration"]
    Neuroinflammation["Neuroinflammation"]
    Glaucoma["Glaucoma"]
    Ischemia["Ischemia"]
    Neuropathy["Neuropathy"]
    Inflammation["Inflammation"]
    Cancer["Cancer"]
    ALS["ALS"]
    Parkinson["Parkinson"]
    Als["Als"]
    NLRP3 -->|"produces"| IL_18
    NLRP3_Inflammasome_Activation -.-|"associated"| IL_18
    NLRP3_Inflammasome_Activation -->|"activates"| IL_18
    NLRP3_Inflammasome -.-|"associated"| IL_18
    NLRP3 -->|"upstream_of"| IL_18
    IL_18 -->|"biomarker_for"| Status_Epilepticus
    IL_18 -->|"regulates"| INFLAMMASOME
    IL_18 -->|"activates"| Neurodegeneration
    IL_18 -->|"activates"| Neuroinflammation
    IL_18 -->|"activates"| Glaucoma
    IL_18 -->|"activates"| Ischemia
    IL_18 -->|"activates"| Neuropathy
    IL_18 -->|"activates"| Inflammation
    IL_18 -->|"expressed in"| Cancer
    IL_18 -->|"expressed in"| ALS
    IL_18 -->|"activates"| Parkinson
    IL_18 -.-|"associated"| Neuroinflammation
    IL_18 -->|"activates"| ALS
    IL_18 -.-|"associated"| Inflammation
    IL_18 -->|"expressed in"| Als
    style IL_18 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px

Outgoing (296)

Target	Relation	Type	Str
neuroinflammation	causes	phenotype	0.90
Status Epilepticus	biomarker_for	disease	0.80
pyroptosis	participates_in	pathway	0.75
Aging	activates	disease	0.65
NF-kB signaling	participates_in	pathway	0.65
Diabetes	activates	disease	0.65
Als	activates	disease	0.65
Alzheimer	contributes_to	disease	0.65
Als	associated_with	disease	0.65
NRF2	transports	gene	0.65
SIRT1	transports	gene	0.65
Epilepsy	activates	disease	0.65
Necroptosis	activates	disease	0.65
Metabolic Syndrome	regulates	disease	0.65
Aging	inhibits	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Pyroptosis	inhibits	disease	0.65
Als	biomarker_for	disease	0.65
Cirrhosis	causes	disease	0.65
Inflammation	causes	disease	0.65
Parkinson	protects_against	disease	0.65
Dementia	inhibits	disease	0.65
Diabetes	protects_against	disease	0.65
oxidative stress response	participates_in	pathway	0.65
Aging	biomarker_for	disease	0.65
Fibrosis	activates	disease	0.65
Als	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Obesity	causes	disease	0.65
Hepatitis	causes	disease	0.65
ALS	causes	disease	0.65
Multiple Sclerosis	expressed_in	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	protects_against	disease	0.65
Necroptosis	inhibits	disease	0.65
Stroke	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
RAGE	activates	gene	0.65
neurons	expressed_in	cell_type	0.65
INFLAMMASOME	regulates	protein	0.65
Alzheimer	activates	disease	0.65
Parkinson	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
ALS	activates	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	expressed_in	disease	0.65
Neuroinflammation	expressed_in	disease	0.65
Als	regulates	disease	0.65
Schizophrenia	biomarker_for	disease	0.65

Incoming (159)

Source	Relation	Type	Str
NLRP3 Inflammasome	associated_with	mechanism	0.90
NLRP3 Inflammasome	activates	gene	0.90
NLRP3	associated_with	protein	0.90
NLRP3 Inflammasome Activation	associated_with	process	0.90
NLRP3 Inflammasome Activation	activates	process	0.90
NLRP3	upregulates	protein	0.90
Guhan Yangsheng Jing	downregulates	drug	0.85
GFAP	biomarker_for	gene	0.65
AMPK	transports	gene	0.65
P53	activates	gene	0.60
BAX	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
PTGS2	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
AIF	regulates	gene	0.60
ALZHEIMER	activates	gene	0.60
IL-1	regulates	gene	0.60
PTGS2	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
NR3C1	associated_with	gene	0.60
BAX	associated_with	gene	0.60
BCL2	associated_with	gene	0.60
AIM2	activates	gene	0.60
ASC	regulates	gene	0.60
ASC	therapeutic_target	gene	0.60
IL-1	activates	gene	0.60
GLAUCOMA	activates	gene	0.60
TCR	expressed_in	gene	0.60
NEURON	activates	gene	0.60
POLE	activates	gene	0.60
PAD4	inhibits	gene	0.60
IL1B	associated_with	gene	0.60
MIRNAS	associated_with	gene	0.60
CYTOKINES	contributes_to	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
INFLAMMATION	associated_with	gene	0.60
TLR4	activates	gene	0.60
MYD88	activates	gene	0.60
PARKINSON	activates	gene	0.60
TRPM7	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
NRF2	activates	gene	0.60
SIRT1	activates	gene	0.60
SYK	activates	gene	0.60
JNK	activates	gene	0.60
TLR4	regulates	gene	0.60
NLRP6	regulates	gene	0.60
AGING	activates	gene	0.60
P21	activates	gene	0.60
GENES	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adapt

molecular biology | 2026-04-16 | 9 hypotheses Top: 0.824

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

neurodegeneration | 2026-04-01 | 7 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthe

closed · Rounds: 4 · Score: 0.71 · 2026-04-16

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning IL-18 in their description or question text

No additional research found

IL-18

Understanding Entity Pages

Summary

Wiki Pages (3)

IL-18 - Interleukin-18

IL-18 Protein

IL-18BP Protein

Pathway Diagram

Outgoing (296)

Incoming (159)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Is APOE4's reduced lipid binding pathogenic or a compensatory evolutionary adapt

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (0)

Related Papers (0)

Debates (2)

The skeptic raised evidence that APOE4 carriers show enhanced cholesterol synthe

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Related Research