Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PEX5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PEX5 |
| Full Name | Peroxisome Biogenesis Factor 5 |
| Aliases | Page for PEX5 Gene, Page for PEX5 Protein |
| Chromosome | 12p13.3 |
| Function | Cargo Recognition: PEX5 binds PTS1-containing proteins (SKL motif) in the cytosol |
| Molecular Weight | 131 kDa |
| Amino Acids | 631 aa |
| UniProt ID | P50571 |
| NCBI Gene ID | 5835 |
| Ensembl ID | ENSG00000120799 |
| GeneCards | PEX5 |
| Human Protein Atlas | PEX5 |
| Primary | ROC curve for VLCFA ratio discrimination (PD vs. controls); target AUC >0.80 |
| Secondary | Correlation with UPDRS-III scores, disease duration, MoCA scores |
| Exploratory | Comparison with disease control group to assess specificity |
| Associated Diseases | multiple sclerosis |
| Interactions | PEX3, GSK3, PPAR, ATM |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
PEX5(["PEX5"])
Cancer["Cancer"]
GSK3(["GSK3"])
PEX3(["PEX3"])
PPAR(["PPAR"])
neurodegeneration["neurodegeneration"]
PEX5 -->|"activates"| Cancer
PEX5 -->|"activates"| GSK3
PEX5 -->|"activates"| PEX3
PPAR -->|"activates"| PEX5
PEX5 -->|"implicated in"| neurodegeneration
style PEX5 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | activates | disease | 0.65 |
| PEX3 | activates | gene | 0.60 |
| GSK3 | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| multiple sclerosis | regulates | disease | 0.60 |
| microglia | expressed_in | cell_type | 0.60 |
| oligodendrocytes | expressed_in | cell_type | 0.60 |
| multiple sclerosis | associated_with | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||