gene 965 words KG: PEX5
Contents

PEX5 Gene - Peroxisome Biogenesis Factor 5

🧬 Gene Info
Gene SymbolPEX5
Full NamePeroxisome Biogenesis Factor 5
AliasesPage for PEX5 Gene, Page for PEX5 Protein
Chromosome12p13.3
FunctionCargo Recognition: PEX5 binds PTS1-containing proteins (SKL motif) in the cytosol
Subcellular Localization**: Cytosol and peroxisomal membrane
Molecular Weight131 kDa
Amino Acids631 aa
UniProt IDP50571
NCBI Gene ID5835
Ensembl IDENSG00000120799
GeneCardsPEX5
Human Protein AtlasPEX5
Associated Diseasesmultiple sclerosis
InteractionsATM, GSK3, PEX3, PPAR
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.77
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Extracellular Vesicle Biogenesis Modulation
Score: 0.58

Related Analyses (5)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Tau propagation mechanisms and therapeutic interception poin
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (2)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40
Cytochrome Therapeutics
clinical · proposed · Score: 0.40

See Also (4)

Neurodegeneration
disease · KG edge: implicated_in
PPAR (Peroxisome Proliferator-Activated Receptor)
entity · KG edge: activates
PEX3 Gene - Peroxisome Biogenesis Factor 3
gene · KG edge: activates
GSK3 Signaling in Parkinson's Disease
mechanism · KG edge: activates

Knowledge Graph (11 edges)

PPAR activates PEX5
PEX5 activates PEX3
ATM interacts_with PEX5
ATM activates PEX5
PEX5 activates GSK3
PEX5 activates Cancer
PEX5 participates_in autophagy pathway
PEX5 regulates multiple sclerosis
PEX5 expressed_in microglia
PEX5 expressed_in oligodendrocytes

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