process

Protein Aggregation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Protein Aggregation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

658Connections

0Hypotheses

5Analyses

49Outgoing

50Incoming

Summary

Protein Aggregation is a biological process related to neurodegeneration research. Key relationships include: associated with, expressed in, activates. Associated with ALS, Aging, Als. Connected to 84 entities in the SciDEX knowledge graph.

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🧬 Biological Process Info

Name	Protein Aggregation
Key Genes/Proteins	Amyloid, HNRNPA2B1, Amyloid-Beta, Tau, SOLUBLE OLIGOMERS
Related Diseases	Alzheimer's Disease, Neurodegenerative Diseases, Neurodegeneration, Neurodegenerative Disease

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Protein_Aggregation["Protein Aggregation"] -->|"involved in"| Amyloid_Beta["Amyloid-Beta"]
    Protein_Aggregation["Protein Aggregation"] -->|"involved in"| Tau["Tau"]
    CERS2["CERS2"] -.->|"inhibits"| Protein_Aggregation["Protein Aggregation"]
    JUN["JUN"] -->|"associated"| Protein_Aggregation["Protein Aggregation"]
    NTN1["NTN1"] -->|"associated"| Protein_Aggregation["Protein Aggregation"]
    NTN3["NTN3"] -->|"associated"| Protein_Aggregation["Protein Aggregation"]
    style Protein_Aggregation fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (91)

Target	Relation	Type	Str
Alzheimer's Disease	causes	disease	0.95
Neurodegenerative Diseases	causes	disease	0.95
Amyloid	associated_with	protein	0.95
Neurodegeneration	associated_with	disease	0.95
Neurodegenerative Diseases	contributes_to	disease	0.92
Amyloid-Beta	involved_in	protein	0.90
Tau	involved_in	protein	0.90
Neuroinflammation	causes	process	0.90
SOLUBLE OLIGOMERS	associated_with	protein	0.90
Neuroplasticity	associated_with	process	0.90
Neurodegenerative Diseases	associated_with	disease	0.90
Neurodegenerative Disease	causes	disease	0.90
Neuronal Degeneration	contributes_to	process	0.90
Alzheimer's Disease	contributes_to	disease	0.85
Neurodegeneration	contributes_to	disease	0.85
ALZHEIMER'S DISEASE	causes	disease	0.85
Neurodegeneration	causes	process	0.85
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.85
Amyotrophic Lateral Sclerosis	causes	disease	0.75
Er Stress	activates	pathway	0.70
Mitochondrial Dysfunction	causes	mechanism	0.70
Transcriptional Dysregulation	causes	mechanism	0.70
ALZHEIMER'S	expressed_in	concept	0.50
AMYLOID-β	expressed_in	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
FRONTOTEMPORAL	associated_with	concept	0.50
Proteostasis	associated_with	process	0.50
Protein Folding	associated_with	pathway	0.50
ENDOPLASMIC RETICULUM	associated_with	concept	0.50
PARKINSON'S	activates	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
NUCLEUS	activates	concept	0.50
INSULIN	activates	concept	0.50
CELL DEATH	activates	concept	0.50
NEURODEGENERATIVE DISEASE	activates	concept	0.50
GLUTAMATE	associated_with	concept	0.50
EXCITOTOXICITY	associated_with	concept	0.50
CELL DEATH	associated_with	concept	0.50
PARKINSON'S	associated_with	concept	0.50
Proteins	inhibits	protein	0.50
HUNTINGTON'S	regulates	concept	0.50
NEUROFIBRILLARY TANGLES	associated_with	concept	0.50
Proteins	interacts_with	protein	0.50
NUCLEUS	interacts_with	concept	0.50
NEURODEGENERATIVE DISEASE	associated_with	concept	0.50
ALZHEIMER'S	activates	concept	0.50
HUNTINGTON'S	activates	concept	0.50
Neuron	associated_with	cell_type	0.50

Incoming (567)

Source	Relation	Type	Str
HNRNPA2B1	contributes_to	protein	0.92
Neuroinflammation	upregulates	process	0.90
Autophagy	associated_with	process	0.90
Proteostasis Disruption	causes	process	0.90
Neurodegeneration-Associated Proteins Accumulation	promotes	phenotype	0.90
SNCA	involved_in	protein	0.90
Amyloid-Beta	involved_in	protein	0.90
TAU	involved_in	protein	0.90
Parkin	regulates	protein	0.90
TARDBP	involved_in	protein	0.90
Intra-Condensate Demixing	mediates	process	0.90
DNAJB6	inhibits	protein	0.90
Intrinsically Disordered Low-Complexity Domain	contributes_to	mechanism	0.90
Molecular Chaperones	suppresses	protein	0.90
PRKAA2	regulates	gene	0.90
Inflammasome	associated_with	pathway	0.88
HSPB8	modulates	protein	0.88
Endoplasmic Reticulum Dysfunction	contributes_to	process	0.85
Proteostasis Network	regulates	pathway	0.85
Environmental Stress	promotes	process	0.85
LGMDD1	associated_with	disease	0.85
Cytoskeletal Disruption	promotes	process	0.85
Protein Clearance Enhancement	suppresses	pathway	0.85
Autophagy	suppresses	process	0.85
APOE	modulates	protein	0.80
Protein Misfolding	causes	mechanism	0.80
Huntingtin	causes	gene	0.80
CERS2	inhibits	gene	0.60
JUN	associated_with	gene	0.60
NTN1	associated_with	gene	0.60
NTN3	associated_with	gene	0.60
SNRNP70	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
AKT	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
C1Q	associated_with	gene	0.60
CLPP	associated_with	gene	0.60
ELAVL2	associated_with	gene	0.60
FUS	associated_with	gene	0.60
IGF2BP1	associated_with	gene	0.60
LONP1	associated_with	gene	0.60
METTL3	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
RAB11	associated_with	gene	0.60
RAB5	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
STX17	associated_with	gene	0.60
CHMP2A	activates	gene	0.60
CHMP2B	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (5)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Protein Aggregation

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Pathway Diagram

Outgoing (91)

Incoming (567)

Targeting Hypotheses (0)

Mentioning Analyses (5)

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

Do SCFAs directly modulate α-synuclein aggregation in vivo at physiologically re

What determines the specificity of DDR protein recruitment to dilncRNA-induced c