Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PI3K-AKT-MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | PI3K-AKT-MTOR |
| Key Genes/Proteins | AMPK |
| Related Diseases | PROSTATE CANCER, CASTRATION-RESISTANT PROSTATE CANCER, Cancer |
Knowledge base pages for this entity
graph TD
PI3K_AKT_MTOR["PI3K-AKT-MTOR"]
PI3K_AKT_MTOR -->|"involved_in"| Prostate_Cancer["Prostate Cancer"]
PI3K_AKT_MTOR -->|"contributes to"| Castration_Resistant_Prostate_["Castration-Resistant Prostate Cancer"]
PI3K_AKT_MTOR -->|"causes"| Ferroptosis_Resistance["Ferroptosis Resistance"]
PI3K_AKT_MTOR -->|"mediates"| Androgen_Deprivation_Therapy_R["Androgen Deprivation Therapy Resistance"]
PI3K_AKT_MTOR -->|"activates"| Cell_Proliferation["Cell Proliferation"]
PI3K_AKT_MTOR -->|"activates"| Cell_Survival["Cell Survival"]
PI3K_AKT_MTOR -->|"regulates"| Protein_Synthesis["Protein Synthesis"]
PI3K_AKT_MTOR -->|"involved_in"| Neurodegeneration["Neurodegeneration"]
SEMA3F["SEMA3F"] -->|"inhibits"| PI3K_AKT_MTOR
RPL36["RPL36"] -->|"inhibits"| PI3K_AKT_MTOR
IGF_1["IGF-1"] -->|"activates"| PI3K_AKT_MTOR| Target | Relation | Type | Str |
|---|---|---|---|
| PROSTATE CANCER | promotes | disease | 0.90 |
| CASTRATION-RESISTANT PROSTATE CANCER | promotes | disease | 0.90 |
| Cancer | involved_in | disease | 0.90 |
| Autophagy | regulates | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMPK | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TREM2-DAP12 Signalosome Enhancement — Boosting PI3K-AKT-mTOR | 0.451 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Trem2-dependent Insl3 regulation via Dap12-Syk-PI3K pathway: A new pathogenic me [PMID:41038403] | Ye S, Wu C, Huang S, Fan H, Zhang Z et a | Genomics | 2025 | 0 |