concept

IGF-1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IGF-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

287Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	IGF-1
Key Genes/Proteins	KL, KIF5B, IL-6
Related Diseases	Ms, Alzheimer, Aging, Inflammation
Related Pathways	Multiplexed Base Editing, ERK, PI3K-Akt-mTOR, insulin signaling

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    IGF_1["IGF-1"]
    style IGF_1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    IGF_1 -->|"activates"| Myogenesis["Myogenesis"]
    IGF_1 -->|"activates"| PI3K_Akt_mTOR["PI3K-Akt-mTOR"]
    IGF_1 -->|"regulates"| insulin_signaling["insulin signaling"]
    IGF_1 -->|"activates"| Ms["Ms"]
    IGF_1 -.->|"inhibits"| Alzheimer["Alzheimer"]
    IGF_1 -.->|"inhibits"| Aging["Aging"]
    IGF_1 -.->|"inhibits"| Inflammation["Inflammation"]
    IGF_1 -.->|"inhibits"| Als["Als"]
    KIF5B([KIF5B]) -->|"regulates"| IGF_1
    ERK["ERK"] -->|"upstream_of"| IGF_1
    AND([AND]) -->|"activates"| IGF_1
    DNM1L([DNM1L]) -->|"activates"| IGF_1
    NEURON([NEURON]) -->|"activates"| IGF_1
    MICROGLIA([MICROGLIA]) -->|"activates"| IGF_1
    MITOCHONDRIAL_DYSFUNCTION([MITOCHONDRIAL DYSFUNCTION]) -->|"activates"| IGF_1
    MTORC1([MTORC1]) -->|"activates"| IGF_1
    IL_6([IL-6]) -.->|"inhibits"| IGF_1
    BDNF([BDNF]) -->|"activates"| IGF_1

Outgoing (167)

Target	Relation	Type	Str
Myogenesis	activates	process	0.85
Synaptic Plasticity	promotes	process	0.85
PI3K-Akt-mTOR	activates	pathway	0.70
insulin signaling	regulates	pathway	0.70
Ms	activates	disease	0.65
Alzheimer	inhibits	disease	0.65
Aging	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Aging	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Diabetes	activates	disease	0.65
Inflammation	activates	disease	0.65
Alzheimer	activates	disease	0.65
Fibrosis	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Aging	biomarker_for	disease	0.65
Inflammation	biomarker_for	disease	0.65
Senescence	biomarker_for	disease	0.65
Depression	activates	disease	0.65
Als	activates	disease	0.65
Als	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
ALS	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Alzheimer	contributes_to	disease	0.65
Als	contributes_to	disease	0.65
Dementia	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Mtor	activates	pathway	0.60
INFLAMMATION	inhibits	gene	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
Akt	activates	pathway	0.60
Endocytosis	activates	pathway	0.60
DIABETES MELLITUS	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
INSULIN RESISTANCE	activates	gene	0.60
BDNF	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
IL-6	activates	gene	0.60
FGF21	activates	gene	0.60
AND	activates	gene	0.60
CYTOKINES	activates	gene	0.60

Incoming (120)

Source	Relation	Type	Str
h-47ab2be5	targets_gene	hypothesis	0.90
KL	modulates	protein	0.85
KIF5B	regulates	gene	0.80
Multiplexed Base Editing	activates	mechanism	0.80
ERK	upstream_of	pathway	0.75
IL-6	associated_with	gene	0.66
AND	activates	gene	0.60
DNM1L	activates	gene	0.60
NEURON	activates	gene	0.60
MICROGLIA	activates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	activates	gene	0.60
MTORC1	activates	gene	0.60
IL-6	inhibits	gene	0.60
AGING	inhibits	gene	0.60
TNF	activates	gene	0.60
EXERCISE	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
TNF-Α	activates	gene	0.60
NEURODEGENERATIVE DISEASES	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
CYTOKINES	associated_with	gene	0.60
VEGF	associated_with	gene	0.60
AGING	activates	gene	0.60
PER	activates	gene	0.60
FOXO1	activates	gene	0.60
MTOR	activates	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
AKT	activates	gene	0.60
INS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
EXERCISE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEUROTOXICITY	activates	gene	0.60
CYTOKINES	activates	gene	0.60
NPY	activates	gene	0.60
FGF21	biomarker_for	gene	0.60
MITOCHONDRIA	biomarker_for	gene	0.60
GPNMB	activates	gene	0.60
COMPLEMENT	activates	gene	0.60
VIMENTIN	biomarker_for	gene	0.60
VIM	biomarker_for	gene	0.60
CXCL10	biomarker_for	gene	0.60
CX3CL1	biomarker_for	gene	0.60
APOPTOSIS	biomarker_for	gene	0.60
APP	activates	gene	0.60
GHRL	activates	gene	0.60
PGRN	biomarker_for	gene	0.60
TGM2	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

CRISPR-based therapeutic approaches for neurodegenerative diseases

neurodegeneration | 2026-04-03 | 14 hypotheses Top: 0.622

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

IGF-1

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Progressive Supranuclear Palsy (PSP)

Novel Therapy Index

Parkinson's Disease

nimodipine-als

Neuroresilience Mechanisms and Evidence

CBS/PSP Treatment Rankings

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy

GSK-3β in Neurodegeneration

Growth Factor Therapies

ALS Failed Approaches Analysis

Oligodendrocytes

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

VEGF/Angiogenesis Pathway in Neurodegeneration

Insulin Signaling in Parkinson's Disease

Growth Factor Therapeutics: Investment Landscape Analysis

IGF-1 Signaling Pathway in Neurodegeneration