Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Down syndrome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| mTOR | associated_with | pathway | 0.80 |
| Alzheimer's disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| 41545595 | causes | paper | 0.90 |
| 34832952 | is associated with | paper | 0.90 |
| CLU | associated_with | gene | 0.70 |
| CR1 | associated_with | gene | 0.70 |
| oxidative stress | activates | process | 0.70 |
| oxidative stress | associated_with | process | 0.70 |
| PI3K-Akt-mTOR | activates | pathway | 0.70 |
| reduced autophagy | associated_with | process | 0.70 |
| autophagy | associated_with | process | 0.70 |
| amyloid beta | biomarker_for | protein | 0.70 |
| tau phosphorylation | biomarker_for | protein | 0.70 |
| AQP4 | associated_with | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning Down syndrome in their description or question text
No additional research found