Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Down syndrome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer's disease | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PI3K-Akt-mTOR | activates | pathway | 0.70 |
| reduced autophagy | associated_with | process | 0.70 |
| autophagy | associated_with | process | 0.70 |
| amyloid beta | biomarker_for | protein | 0.70 |
| tau phosphorylation | biomarker_for | protein | 0.70 |
| CLU | associated_with | gene | 0.70 |
| CR1 | associated_with | gene | 0.70 |
| oxidative stress | activates | process | 0.70 |
| oxidative stress | associated_with | process | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||