gene

ar

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ar: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

178Connections
30Hypotheses
30Analyses
50Outgoing
14Incoming

No summary available yet. View on Wiki →

🧬 Gene Info
Gene SymbolAR
ChromosomeXq12
Protein TypeGene
Functionencodes a nuclear receptor protein that binds testosterone and dihydrotestosterone, mediating the effects of androgen hormones in target tissues.
Primary Expressionbrain regions including: - Spinal cord: Motor neurons, including those innervating skeletal muscle - Hypothalamus: Regulatory centers for hor
Molecular Weight110 kDa
Amino Acids919 aa
GeneCardsAR
Human Protein AtlasAR
Associated Diseasesneurodegeneration
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Pathway Diagram

graph TD
    AR["AR"]
    AR -->|"contributes to"| Androgen_Deprivation_Therapy_R["Androgen Deprivation Therapy Resistance"]
    AR -->|"participates in"| oxidative_stress_response["oxidative stress response"]
    AR -->|"participates in"| autophagy_pathway["autophagy pathway"]
    AR -->|"inhibits"| IL12A["IL12A"]
    AR -->|"regulates"| Prostate_Cancer_Cell_Survival["Prostate Cancer Cell Survival"]
    AR -->|"activates"| BECN1["BECN1"]
    AR -->|"activates"| MAP1LC3B["MAP1LC3B"]
    AR -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
    PI3K_AKT_mTOR["PI3K-AKT-mTOR"] -->|"interacts"| AR
    Stress_Granules["Stress Granules"] -->|"modulates"| AR
    rapamycin["rapamycin"] -->|"targets"| AR
    ALS["ALS"] -->|"activates"| AR
    ACTB["ACTB"] -->|"activates"| AR
    AMBRA1["AMBRA1"] -->|"activates"| AR
    AMPK["AMPK"] -->|"activates"| AR
    APP["APP"] -->|"activates"| AR

Outgoing (164)

TargetRelationTypeStr
SLIRPinteracts_withprotein0.95
IGFBP5interacts_withprotein0.95
Androgen Deprivation Therapy Resistancecontributes_tophenotype0.90
Metabolic Adaptationmodulatesprocess0.90
oxidative stress responseparticipates_inpathway0.90

Incoming (14)

SourceRelationTypeStr
SPOPdegradesprotein0.90
PI3K-AKT-mTORinteracts_withpathway0.85
Stress Granulesmodulatesprocess0.85
SPOP mutationspromotesphenotype0.85
rapamycintargetsdrug0.70

Targeting Hypotheses (30)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
Multi-Target Hypothesis: Aβ-Induced Cholinergic Damage is Pa 0.700 - Do β-amyloid plaques and neurofibrillary
Closed-loop tACS targeting EC-II SST interneurons to block t 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop focused ultrasound targeting EC-II SST interneur 0.697 Alzheimer's disease Circuit-level neural dynamics in neurode
CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind 0.674 neuroimmunology What is the temporal sequence of TREM2 s
Closed-loop tACS targeting EC-II PV interneurons to suppress 0.670 Alzheimer's disease Circuit-level neural dynamics in neurode
Beta-frequency entrainment therapy targeting PV interneuron- 0.669 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting EC-II parvalbumin interneurons to 0.660 Alzheimer's disease Circuit-level neural dynamics in neurode
STMN2 Restoration as a Prerequisite for Axon Growth After TD 0.658 neurodegeneration What molecular mechanisms enable functio
Beta-Hydroxybutyrate Receptor (HCAR2) Signaling Links Ketone 0.645 neurodegeneration What are the precise temporal dynamics o
Closed-loop transcranial focused ultrasound targeting EC-II 0.633 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop optogenetic targeting PV interneurons to restore 0.633 Alzheimer's disease Circuit-level neural dynamics in neurode
Closed-loop tACS targeting entorhinal cortex layer II SST in 0.625 Alzheimer's disease Circuit-level neural dynamics in neurode
Circadian Glymphatic Entrainment via Targeted Orexin Recepto 0.623 neurodegeneration Perivascular spaces and glymphatic clear
CSF Biomarker-Guided ABCA7 Therapeutic Dosing 0.619 neurodegeneration Why does the V1613M variant reduce amylo
Integrated Biomarker Panel for Therapeutic Window Identifica 0.615 neurodegeneration What are the precise temporal dynamics o
Closed-loop focused ultrasound targeting CA1 PV interneurons 0.614 Alzheimer's disease Circuit-level neural dynamics in neurode
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D 0.614 neurodegeneration What is the molecular mechanism by which
Closed-loop transcranial focused ultrasound targeting EC-II 0.612 Alzheimer's disease Circuit-level neural dynamics in neurode
Aryl Hydrocarbon Receptor (AHR) Activation in B Cells Determ 0.612 neuroinflammation How do B cells mechanistically orchestra
Targeting SASP-Complement Amplification Through HIF-1α Downs 0.610 neurodegeneration What molecular mechanism causes VCP muta
DLK MAPK Pathway Inhibition to Block Tau-Induced Neurotoxici 0.609 neurodegeneration Should microtubule-stabilizing drugs be
TREM2-Microglial Clearance Enhancement as Common Mechanism f 0.604 neurodegeneration Why do p300/CBP inhibitors reduce both A
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 0.601 neurodegeneration What are the mechanisms by which gut mic
Multi-Modal Stress Response Harmonization 0.601 neurodegeneration Digital biomarkers and AI-driven early d
HSPB1 Phosphorylation Mimetics to Promote Protective TDP-43 0.598 neurodegeneration What is the therapeutic window between i
C3aR Blockade Disrupts the Microglial-Astrocyte Feedforward 0.596 neuroinflammation What molecular mechanisms determine whet
H7: Enteric Nervous System Alpha-Synuclein Propagation Block 0.595 neurodegeneration How does engineered C. butyricum cross t
Selective APOE4 Degradation via Proteolysis Targeting Chimer 0.595 neurodegeneration APOE4 structural biology and therapeutic
Aryl Hydrocarbon Receptor (AhR) Activation by Microbiome Met 0.593 neuroinflammation What molecular mechanisms determine whet
M1 Muscarinic Receptor Agonism as Pharmacological Exercise S 0.589 neurodegeneration What are the specific circulating factor

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the cell-type-specific transcriptomic signatures of vulnerability in SE

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576

How do synthetic EVs achieve brain-specific targeting while avoiding reticuloend

drug delivery | 2026-04-15 | 0 hypotheses

Are age-related static epigenetic patterns pathogenic or protective compensatory

epigenetics | 2026-04-15 | 0 hypotheses

What determines the GPX4/ACSL4 balance that switches microglia from protective t

immunology | 2026-04-15 | 0 hypotheses

What molecular mechanisms mediate SPP1-induced microglial phagocytic activation

neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] Yang S, Wang X, Yan Y, Zhang J, Wei Y et J Affect Disord 2026 0
Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361] Han SC, Han J, Min YK, Han JW, Jeong HJ Am J Sports Med 2026 0
External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] Vadalà A, Benelli C, Suraci F, Carta B, Arch Orthop Trauma Surg 2026 0
Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967] Huang X, Francis I, Gu Y, Saha SC Respir Physiol Neurobiol 2026 0
Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313] Samante FI, Galangue CG, Avelino DC, Bel Pharmacol Rep 2026 0
Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213] Wu J, Lin B, Yang S, Xu S, Li S J Prosthet Dent 2026 0
Fate plasticity of interneuron specification. [PMID:40264797] Mostajo-Radji MA, Leon WRM, Breevoort A, iScience 2025 0
Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] Bershteyn M, Zhou H, Fuentealba L, Chen Neuron 2025 0
Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] Walsh RM, Crabtree GW, Kalpana K, Jubier Neuron 2025 0
Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040] Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK Autophagy 2024 0
Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] Gabitto MI, Travaglini KJ, Rachleff VM, Nat Neurosci 2024 0
Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] Wang W, Lu J, Pan N, Zhang H, Dai J et a Front Immunol 2024 0
Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135] Walsh RM, Crabtree GW, Kalpana K, Jubier bioRxiv 2024 0
Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] Fogaça MV, Wu M, Li C, Li XY, Picciotto Mol Psychiatry 2021 0
Identification of epilepsy-associated neuronal subtypes and gene expression unde [PMID:33028830] Pfisterer U, Petukhov V, Demharter S, Me Nat Commun 2020 0