Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ar: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | AR |
| Chromosome | Xq12 |
| Protein Type | Gene |
| Function | encodes a nuclear receptor protein that binds testosterone and dihydrotestosterone, mediating the effects of androgen hormones in target tissues. |
| Primary Expression | brain regions including: - Spinal cord: Motor neurons, including those innervating skeletal muscle - Hypothalamus: Regulatory centers for hor |
| Molecular Weight | 110 kDa |
| Amino Acids | 919 aa |
| GeneCards | AR |
| Human Protein Atlas | AR |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
AR["AR"]
AR -->|"contributes to"| Androgen_Deprivation_Therapy_R["Androgen Deprivation Therapy Resistance"]
AR -->|"participates in"| oxidative_stress_response["oxidative stress response"]
AR -->|"participates in"| autophagy_pathway["autophagy pathway"]
AR -->|"inhibits"| IL12A["IL12A"]
AR -->|"regulates"| Prostate_Cancer_Cell_Survival["Prostate Cancer Cell Survival"]
AR -->|"activates"| BECN1["BECN1"]
AR -->|"activates"| MAP1LC3B["MAP1LC3B"]
AR -->|"participates in"| epigenetic_regulation["epigenetic regulation"]
PI3K_AKT_mTOR["PI3K-AKT-mTOR"] -->|"interacts"| AR
Stress_Granules["Stress Granules"] -->|"modulates"| AR
rapamycin["rapamycin"] -->|"targets"| AR
ALS["ALS"] -->|"activates"| AR
ACTB["ACTB"] -->|"activates"| AR
AMBRA1["AMBRA1"] -->|"activates"| AR
AMPK["AMPK"] -->|"activates"| AR
APP["APP"] -->|"activates"| AR| Target | Relation | Type | Str |
|---|---|---|---|
| SLIRP | interacts_with | protein | 0.95 |
| IGFBP5 | interacts_with | protein | 0.95 |
| Androgen Deprivation Therapy Resistance | contributes_to | phenotype | 0.90 |
| Metabolic Adaptation | modulates | process | 0.90 |
| oxidative stress response | participates_in | pathway | 0.90 |
| autophagy pathway | participates_in | pathway | 0.90 |
| Aromatase Inhibitor Resistance | associated_with | phenotype | 0.85 |
| IL12A | inhibits | gene | 0.80 |
| Prostate Cancer Cell Survival | regulates | phenotype | 0.80 |
| BECN1 | activates | gene | 0.80 |
| MAP1LC3B | activates | gene | 0.80 |
| androgen deprivation therapy resistance | mediates | phenotype | 0.80 |
| epigenetic regulation | participates_in | pathway | 0.80 |
| Sex Differences In Autophagy | modulates | mechanism | 0.75 |
| Autophagy | regulates | process | 0.75 |
| BCL2 | activates | gene | 0.70 |
| GAPDH | activates | gene | 0.70 |
| GLA | activates | gene | 0.70 |
| LAMP1 | activates | gene | 0.70 |
| MTOR | activates | gene | 0.70 |
| SQSTM1 | activates | gene | 0.70 |
| TFEB | activates | gene | 0.70 |
| HDAC6 | activates | gene | 0.70 |
| PIK3C3 | activates | gene | 0.70 |
| UVRAG | activates | gene | 0.70 |
| CHMP4B | activates | gene | 0.70 |
| ATG | activates | gene | 0.70 |
| RNA | activates | gene | 0.70 |
| Parkinson's disease | activates | disease | 0.70 |
| stem cells | expressed_in | cell_type | 0.70 |
| GABA | activates | gene | 0.70 |
| Parkinson's disease | interacts_with | disease | 0.70 |
| MAPK signaling | participates_in | pathway | 0.70 |
| BAG3 | activates | gene | 0.60 |
| CTSB | activates | gene | 0.60 |
| HSPA8 | activates | gene | 0.60 |
| HSPB8 | activates | gene | 0.60 |
| LAMP2A | activates | gene | 0.60 |
| LGALS3 | activates | gene | 0.60 |
| MCOLN1 | activates | gene | 0.60 |
| PPARGC1A | activates | gene | 0.60 |
| PPP3CB | activates | gene | 0.60 |
| SOD1 | activates | gene | 0.60 |
| STIP1 | activates | gene | 0.60 |
| STUB1 | activates | gene | 0.60 |
| TARDBP | activates | gene | 0.60 |
| TPP1 | activates | gene | 0.60 |
| TREH | activates | gene | 0.60 |
| neurodegeneration | activates | disease | 0.60 |
| ATG14 | activates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SPOP | degrades | protein | 0.90 |
| PI3K-AKT-mTOR | interacts_with | pathway | 0.85 |
| Stress Granules | modulates | process | 0.85 |
| SPOP mutations | promotes | phenotype | 0.85 |
| rapamycin | targets | drug | 0.70 |
| ACTB | activates | gene | 0.60 |
| AMBRA1 | activates | gene | 0.60 |
| APP | activates | gene | 0.60 |
| AKT | associated_with | gene | 0.60 |
| AKT | inhibits | gene | 0.60 |
| ALOX12 | associated_with | gene | 0.60 |
| ALS | activates | gene | 0.60 |
| AMPK | activates | gene | 0.60 |
| benchmark_ot_ad_answer_key:AR | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.576
drug delivery | 2026-04-15 | 0 hypotheses
epigenetics | 2026-04-15 | 0 hypotheses
immunology | 2026-04-15 | 0 hypotheses
neuroinflammation | 2026-04-15 | 1 hypotheses Top: 0.650
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Gray matter structural and molecular signatures in Alzheimer's disease and late- [PMID:41419068] | Yang S, Wang X, Yan Y, Zhang J, Wei Y et | J Affect Disord | 2026 | 0 |
| Duloxetine Improves Early Clinical Outcomes Including Range of Motion, Functiona [PMID:41934361] | Han SC, Han J, Min YK, Han JW, Jeong HJ | Am J Sports Med | 2026 | 0 |
| External fixation versus reverse shoulder arthroplasty for proximal humerus frac [PMID:41940987] | Vadalà A, Benelli C, Suraci F, Carta B, | Arch Orthop Trauma Surg | 2026 | 0 |
| Modeling and simulation of conducting airways during continuous high-frequency o [PMID:41941967] | Huang X, Francis I, Gu Y, Saha SC | Respir Physiol Neurobiol | 2026 | 0 |
| Potential antidepressant properties of aminophylline in male mice exposed to chr [PMID:41945313] | Samante FI, Galangue CG, Avelino DC, Bel | Pharmacol Rep | 2026 | 0 |
| Robot-assisted immediate implant placement with the socket shield technique in t [PMID:41963213] | Wu J, Lin B, Yang S, Xu S, Li S | J Prosthet Dent | 2026 | 0 |
| Fate plasticity of interneuron specification. [PMID:40264797] | Mostajo-Radji MA, Leon WRM, Breevoort A, | iScience | 2025 | 0 |
| Human stem cell-derived GABAergic interneuron development reveals early emergenc [PMID:40651475] | Bershteyn M, Zhou H, Fuentealba L, Chen | Neuron | 2025 | 0 |
| Forebrain assembloids support the development of fast-spiking human PVALB+ corti [PMID:40695284] | Walsh RM, Crabtree GW, Kalpana K, Jubier | Neuron | 2025 | 0 |
| Targeting SARM1 improves autophagic stress-induced axonal neuropathy. [PMID:37561040] | Kim HR, Lee HJ, Jeon Y, Jang SY, Shin YK | Autophagy | 2024 | 0 |
| Integrated multimodal cell atlas of Alzheimer's disease. [PMID:39402379] | Gabitto MI, Travaglini KJ, Rachleff VM, | Nat Neurosci | 2024 | 0 |
| Identification of early Alzheimer's disease subclass and signature genes based o [PMID:39650656] | Wang W, Lu J, Pan N, Zhang H, Dai J et a | Front Immunol | 2024 | 0 |
| Cortical assembloids support the development of fast-spiking human PVALB+ cortic [PMID:39651135] | Walsh RM, Crabtree GW, Kalpana K, Jubier | bioRxiv | 2024 | 0 |
| Inhibition of GABA interneurons in the mPFC is sufficient and necessary for rapi [PMID:33070149] | Fogaça MV, Wu M, Li C, Li XY, Picciotto | Mol Psychiatry | 2021 | 0 |
| Identification of epilepsy-associated neuronal subtypes and gene expression unde [PMID:33028830] | Pfisterer U, Petukhov V, Demharter S, Me | Nat Commun | 2020 | 0 |