protein

PINK1-PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PINK1-PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

0Connections

0Hypotheses

0Analyses

0Outgoing

0Incoming

0Experiments

0Debates

Summary

PINK1

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🔬 Protein Info

Gene Symbol	PINK1
Full Name	PROTEIN
Chromosome	1p36.12
Protein Family	Serine/threonine kinase family
Protein Type	Kinase
Function	is a mitochondrial serine/threonine-protein kinase encoded by the PINK1 gene [@zheng2021].
Primary Expression	Mitochondrial outer membrane
Molecular Weight	63 kDa
Pathways	Amyloid, Apoptosis, Autophagy, Chaperone, Cholesterol
UniProt ID	Q9BXM7
NCBI Gene ID	65018
Ensembl ID	ENSG00000158828
OMIM	608309
GeneCards	PINK1
Human Protein Atlas	PINK1
Associated Diseases	AD, Aging, ALI, Als, Alzheimer
Known Drugs/Compounds	BGP-15, Canagliflozin, CANAGLIFLOZIN, DEFERIPRONE, dimethyl fumarate, Gastrodin
Interactions	ABCD3, ABP, ACHE, Actin, AD, AGING
SciDEX Hypotheses	Dose-Response Framework: PINK1/Parkin Mitophagy as Mitophagy collapse via PINK1-PRKN is the primary a PINK1/PARK2-Mediated Mitophagy Enhancement for Neu (+5 more)
KG Connections	3557 knowledge graph edges
Databases	GeneCards HPA STRING

🧬 3D Structure Comparison — PINK1-PROTEIN Experimental (PDB) vs Predicted (AlphaFold) — click to expand

📄 Experimental Structure

6EQI — X-ray / Cryo-EM

🔮 AI Predicted Structure

Q9BXM7 — AlphaFold

Left: Experimental structure from RCSB PDB | Right: AI-predicted structure from AlphaFold | Powered by Mol*

Pathway Diagram

graph TD
    PINK1["PINK1"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    PINK1 -->|"interacts_with"| OXIDATIVE_STRESS
    MTOR["MTOR"]
    PINK1 -->|"activates"| MTOR
    PARL["PARL"]
    PINK1 -->|"regulates"| PARL
    AUTOPHAGY["AUTOPHAGY"]
    PINK1 -->|"expressed_in"| AUTOPHAGY
    CYTOKINES["CYTOKINES"]
    PINK1 -->|"activates"| CYTOKINES
    Cell_Division["Cell Division"]
    PINK1 -->|"activates"| Cell_Division
    PARKIN["PARKIN"]
    PINK1 -->|"interacts_with"| PARKIN
    NLR["NLR"]
    PINK1 -->|"activates"| NLR
    GENES["GENES"]
    PINK1 -->|"implicated_in"| GENES
    mitochondria["mitochondria"]
    PINK1 -->|"activates"| mitochondria
    astrocytes["astrocytes"]
    PINK1 -->|"implicated_in"| astrocytes
    Tumor["Tumor"]
    PINK1 -->|"inhibits"| Tumor
    style PINK1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0
    style OXIDATIVE_STRESS fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style MTOR fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PARL fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style AUTOPHAGY fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style CYTOKINES fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Cell_Division fill:#1b5e20,stroke:#333,stroke-width:1px,color:#e0e0e0
    style PARKIN fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style NLR fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style GENES fill:#006494,stroke:#333,stroke-width:1px,color:#e0e0e0
    style mitochondria fill:#455a64,stroke:#333,stroke-width:1px,color:#e0e0e0
    style astrocytes fill:#01579b,stroke:#333,stroke-width:1px,color:#e0e0e0
    style Tumor fill:#ef5350,stroke:#333,stroke-width:1px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PINK1-PROTEIN in their description or question text

No additional research found