Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PLCB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PLCB4 |
| Full Name | Phospholipase C Beta 4 |
| Chromosome | 20p12.3 |
| Protein Type | Receptor |
| Function | Upon receptor activation, the Gαq subunit activates PLCB4, which then hydrolyzes PIP2 in the plasma membrane |
| Primary Expression | Purkinje cells, mediating signaling from: - Metabotropic glutamate receptors (mGluR1): Critical for cerebellar LTD - Muscarinic acetylcholine re |
| Molecular Weight | 135 kDa |
| Amino Acids | 175 aa |
| Exons | 33 |
| Pathways | Calcium Signaling, Long-Term Potentiation, amyloid aggregation, calcium signaling, synaptic plasticity |
| Ensembl ID | ENSG00000151327 |
| GeneCards | PLCB4 |
| Human Protein Atlas | PLCB4 |
| DAG | Activates protein kinase C (PKC) isoforms |
| IP3 | Binds IP3 receptors on the endoplasmic reticulum, triggering calcium release |
| Associated Diseases | Alzheimer |
| Interactions | ADAM10 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
PLCB4["<b>PLCB4</b>"]
Alzheimer{"Alzheimer"}
PLCB4 -->|"therapeutic target"| Alzheimer
Aging{"Aging"}
PLCB4 -->|"therapeutic target"| Aging
ADAM10["ADAM10"]
PLCB4 -->|"activates"| ADAM10
Long_Term_Potentiation(["Long-Term Potentiation"])
PLCB4 -->|"activates"| Long_Term_Potentiation
Calcium_Signaling(["Calcium Signaling"])
PLCB4 -->|"activates"| Calcium_Signaling
neurodegeneration["neurodegeneration"]
PLCB4 -->|"implicated in"| neurodegeneration
style PLCB4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Alzheimer | therapeutic_target | disease | 0.65 |
| Aging | therapeutic_target | disease | 0.65 |
| ADAM10 | activates | gene | 0.60 |
| calcium signaling | activates | process | 0.60 |
| Long-Term Potentiation | activates | pathway | 0.60 |
| Calcium Signaling | activates | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| amyloid aggregation | activates | process | 0.60 |
| Alzheimer | associated_with | disease | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||