biological_process

synaptic plasticity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about synaptic plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1707Connections

1Hypotheses

0Analyses

35Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Biological Process Info

Name	synaptic plasticity
Key Genes/Proteins	BDNF, REELIN
Related Diseases	Alzheimer's disease, depression, neuroinflammation
Related Pathways	WNT
Linked Hypotheses	6 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    synaptic_plasticity["synaptic plasticity"] -->|"active in"| neurons["neurons"]
    style neurons fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"active in"| hippocampus["hippocampus"]
    style hippocampus fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"active in"| astrocytes["astrocytes"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"mediates"| learning_and_memory["learning and memory"]
    style learning_and_memory fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"mediates"| cognitive_function["cognitive function"]
    style cognitive_function fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"active in"| microglia["microglia"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    synaptic_plasticity["synaptic plasticity"] -->|"crosstalk with"| unfolded_protein_response["unfolded protein response"]
    style unfolded_protein_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    WNT["WNT"] -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    style WNT fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    BDNF["BDNF"] -->|"associated"| synaptic_plasticity["synaptic plasticity"]
    style BDNF fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FTO_inhibition["FTO inhibition"] -->|"promotes"| synaptic_plasticity["synaptic plasticity"]
    style FTO_inhibition fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    REELIN["REELIN"] -->|"regulates"| synaptic_plasticity["synaptic plasticity"]
    style REELIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Alzheimer_s_disease["Alzheimer's disease"] -->|"involves"| synaptic_plasticity["synaptic plasticity"]
    style Alzheimer_s_disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    style synaptic_plasticity fill:#5d4400,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (198)

Target	Relation	Type	Str
neurons	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.90
astrocytes	active_in	cell_type	0.90
learning and memory	mediates	process	0.90
cognitive function	mediates	phenotype	0.84
microglia	active_in	cell_type	0.80
unfolded protein response	crosstalk_with	pathway	0.80
Major depressive disorder	associated_with	disease	0.70
cortex	active_in	brain_region	0.70
calcium signaling	mediates	process	0.70
cerebral cortex	active_in	brain_region	0.70
interneurons	active_in	cell_type	0.70
neural stem cells	active_in	cell_type	0.70
pyramidal neurons	active_in	cell_type	0.70
dentate gyrus	active_in	brain_region	0.70
oligodendrocytes	active_in	cell_type	0.70
striatum	active_in	brain_region	0.60
thalamus	active_in	brain_region	0.60
hypothalamus	active_in	brain_region	0.60
cerebellum	active_in	brain_region	0.60
synaptic pruning	mediates	process	0.60
phagocytosis	mediates	process	0.60
amyloid aggregation	mediates	process	0.60
VGLUT1	activates	gene	0.60
TRKB	activates	gene	0.60
GABAergic neurons	active_in	cell_type	0.60
amygdala	active_in	brain_region	0.60
brainstem	active_in	brain_region	0.60
entorhinal cortex	active_in	brain_region	0.60
blood-brain barrier	active_in	brain_region	0.60
Alzheimer's Disease	associated_with	disease	0.50
Schizophrenia	associated_with	disease	0.50
Depression	associated_with	disease	0.50
SYNCRIP	co_mentioned	gene	0.40
TRKB	co_mentioned	gene	0.40

Incoming (1509)

Source	Relation	Type	Str
WNT	regulates	pathway	0.95
BDNF	associated_with	protein	0.90
BDNF	regulates	protein	0.90
BDNF	modulates	protein	0.90
BDNF	promotes	protein	0.90
FTO inhibition	promotes	process	0.90
REELIN	regulates	protein	0.90
Alzheimer's disease	involves	disease	0.90
depression	involves	disease	0.90
BDNF	participates_in	gene	0.90
neuroinflammation	involves	disease	0.90
neurodegeneration	involves	disease	0.90
APP	participates_in	gene	0.90
TDP-43	impairs	protein	0.90
NMDA receptor	activates	receptor	0.90
ERK	promotes	protein	0.88
SIRT1	modulates	protein	0.85
neurons	active_in	cell_type	0.85
APOE4	participates_in	gene	0.85
activated microglia	inhibits	cell_type	0.85
microglia	regulates	cell_type	0.85
MTOR	associated_with	gene	0.85
DNA methylation	involved_in	process	0.85
APOE	associated_with	gene	0.85
MTOR	involved_in	gene	0.85
protein synthesis	drives	process	0.85
IL-6	promotes	protein	0.80
aging	involves	disease	0.80
HDAC3	participates_in	gene	0.80
PS1	participates_in	gene	0.80
FNDC5	promotes	gene	0.80
CPLX2	involved_in	gene	0.80
NPTX2	promotes	gene	0.80
astrocytes	active_in	cell_type	0.75
APOE3	participates_in	gene	0.75
PSD-95	participates_in	gene	0.75
ARC	participates_in	gene	0.75
CREB1	participates_in	gene	0.75
physical exercise	regulates	process	0.70
APOE4	inhibits	protein	0.70
TrkB-FL	regulates	protein	0.70
PI3K/AKT	regulates	pathway	0.70
PI3K/AKT pathway	regulates	pathway	0.70
SXD	activates	drug	0.70
epigenetic alterations	regulates	process	0.70
Syt1	associated_with	protein	0.70
histone acetylation	regulates	process	0.70
chromatin remodeling	regulates	process	0.70
PTEN	regulates	protein	0.70
IGF2	regulates	protein	0.70

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Sleep Spindle-Synaptic Plasticity Enhancement	0.491	neurodegeneration	Sleep disruption as cause and consequenc

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Effects of caffeine on sleep and cognition. [PMID:21531247]	Snel J, Lorist MM	Prog Brain Res	2011	1
Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808]	Kunttas-Tatli E, Bose A, Kahali B, Bisho	Genesis	2009	1
CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970]	Lu W, Kawatani K, Ren Y	Alzheimers Res Ther	2026	0
Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536]	Zheng ZW, Min PX, Luo YL, Mao XF, Zhang	Neuron	2026	0
Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remod [PMID:41932329]	Thompson SJ, Miao QL, Sonig A, Noebels J	Neuron	2026	0
Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108]	Pruitt A, Yang L, Lee S, Balafkan N, Sea	bioRxiv : the preprint server	2026	0
Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098]	["Oristrell J", "Oliva J", "Casado E", "	Journal of endocrinological in	2022	0
Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388]	Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y,	Seizure	2022	0
Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341]	Rátkai A, Tárnok K, Aouad HE, Micska B,	Scientific reports	2021	0
Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196]	["Zhu X", "Zhou B", "Pattni R", "Gleason	Nature neuroscience	2021	0
Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213]	["Su Z", "Zhang K", "Kappel K", "Li S",	Nature	2021	0
Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251]	["van Loveren F", "van Berlo-van de Laar	Journal of geriatric oncology	2021	0
Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069]	Lory P, Nicole S, Monteil A	Pflugers Archiv : European jou	2020	0
Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633]	["Corces M", "Shcherbina A", "Kundu S",	Nature genetics	2020	0
Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530]	["Gerasimaviciute V", "B\u00fcltmann U",	Injury prevention : journal of	2020	0
On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575]	["Li D", "Li S", "Xie Y", "Hua X", "Long	Nature communications	2019	0
STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212]	["Dulson S", "Watkins E", "Crossman D",	Journal of immunology (Baltimo	2019	0
Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119]	["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag	Orphanet journal of rare disea	2018	0
Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266]	["Azhar A", "Aljefri H"]	Pediatric cardiology	2018	0
Interstitial lung abnormalities and self-reported health and functional status. [PMID:29317545]	["Axelsson G", "Putman R", "Araki T", "S	Thorax	2018	0

synaptic plasticity

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Neuroresilience Mechanisms and Evidence

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings

GRIA3 Gene

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy