pathway

Long-Term Potentiation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Long-Term Potentiation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

295Connections

0Hypotheses

0Analyses

16Outgoing

50Incoming

Summary

Long-Term Potentiation is a biological pathway involved in neurodegeneration research. Key relationships include: activates, regulates, inhibits. Associated with ALS, Aging, Als. Connected to 113 entities in the SciDEX knowledge graph.

View on Wiki →

🔀 Pathway Info

Name	Long-Term Potentiation
Summary	Fixed References section
Key Genes/Proteins	NRG1, ALZHEIMER'S DISEASE, COMPLEMENT, AMYLOID, ALZHEIMER
Related Diseases	Alzheimer'S Disease, Learning and Memory, Learning And Memory, Alzheimer
Related Pathways	Nrg1-Erbb4 Signaling, Reduced Lactate Shuttling

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Complement["Complement"]
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Autophagy["Autophagy"]
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Nf__b["Nf-Kappab"]
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Apoptosis["Apoptosis"]
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Synaptic_Plasticity["Synaptic Plasticity"]
    Long_Term_Potentiation["Long-Term Potentiation"] -->|"interacts"| Calcium_Signaling["Calcium Signaling"]
    JUN["JUN"] -->|"regulates"| Long_Term_Potentiation["Long-Term Potentiation"]
    C1Q["C1Q"] -->|"associated"| Long_Term_Potentiation["Long-Term Potentiation"]
    ANXA1["ANXA1"] -->|"therapeutic target"| Long_Term_Potentiation["Long-Term Potentiation"]
    NBR1["NBR1"] -->|"therapeutic target"| Long_Term_Potentiation["Long-Term Potentiation"]
    style Long_Term_Potentiation fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (34)

Target	Relation	Type	Str
Learning and Memory	mediates	phenotype	0.85
Learning And Memory	associated_with	phenotype	0.85
Hippocampus	expressed_in	cell_type	0.80
Complement	interacts_with	pathway	0.55
Autophagy	interacts_with	pathway	0.55
Nf-Κb	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Synaptic Plasticity	interacts_with	pathway	0.55
Calcium Signaling	interacts_with	pathway	0.55
STRIATUM	interacts_with	concept	0.50
CEREBRAL CORTEX	interacts_with	concept	0.50
Protein Aggregation	activates	process	0.50
INSULIN	activates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Proteins	activates	protein	0.50
ALZHEIMER'S	regulates	concept	0.50

Incoming (261)

Source	Relation	Type	Str
Alzheimer'S Disease	associated_with	disease	0.95
Beta-Amyloid Oligomers	inhibits	compound	0.88
NRG1	regulates	gene	0.85
Parvalbumin-Containing Interneurons	involved_in	cell_type	0.85
Nrg1-Erbb4 Signaling	mediates	pathway	0.85
Reduced Lactate Shuttling	associated_with	mechanism	0.85
Ketogenic Diet	associated_with	drug	0.80
Alzheimer	inhibits	disease	0.70
ALZHEIMER'S DISEASE	inhibits	gene	0.70
COMPLEMENT	regulates	gene	0.70
AMYLOID	inhibits	gene	0.70
ALZHEIMER	inhibits	gene	0.70
Als	regulates	disease	0.65
JUN	regulates	gene	0.60
C1Q	associated_with	gene	0.60
ANXA1	therapeutic_target	gene	0.60
NBR1	therapeutic_target	gene	0.60
CX3CR1	associated_with	gene	0.60
TNF	therapeutic_target	gene	0.60
NTS	associated_with	gene	0.60
NRG1	expressed_in	gene	0.60
ERBB4	expressed_in	gene	0.60
BDNF	activates	gene	0.60
TRKB	activates	gene	0.60
MMP9	inhibits	gene	0.60
SST	inhibits	gene	0.60
MMP3	inhibits	gene	0.60
Inflammation	regulates	disease	0.60
Alzheimer	regulates	disease	0.60
Neuroinflammation	regulates	disease	0.60
Stroke	therapeutic_target	disease	0.60
Aging	therapeutic_target	disease	0.60
Ischemia	therapeutic_target	disease	0.60
Als	activates	disease	0.60
Ms	activates	disease	0.60
PLCB4	activates	gene	0.60
ADAM10	activates	gene	0.60
Alzheimer	therapeutic_target	disease	0.60
Als	associated_with	disease	0.60
Ms	regulates	disease	0.60
ANXA1	protects_against	gene	0.60
NBR1	protects_against	gene	0.60
TNF	protects_against	gene	0.60
TRKB	regulates	gene	0.60
GABARAP	inhibits	gene	0.60
LC3B	associated_with	gene	0.60
GABARAPL2	associated_with	gene	0.60
P62	associated_with	gene	0.60
LC3	associated_with	gene	0.60
ERK	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Long-Term Potentiation

Understanding Entity Pages

Summary

Wiki Pages (21)