pathway

Calcium Signaling

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Calcium Signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

580Connections

1Hypotheses

0Analyses

34Outgoing

50Incoming

Summary

Calcium Signaling is a biological pathway involved in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with ALS, Aging, Als. Connected to 219 entities in the SciDEX knowledge graph.

View on Wiki →

🔀 Pathway Info

Name	Calcium Signaling
Summary	Page for Calcium Signaling — Investment Landscape Analysis
Key Genes/Proteins	ANNEXINS, APOE, Voltage-Gated Calcium Channels, APOPTOSIS
Related Diseases	Als, Alzheimer
Related Pathways	Er-Plasma Membrane Junctions, ER-Mitochondria Contact Sites, ER-Plasma Membrane Junctions
Linked Hypotheses	2 hypotheses

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    Calcium_Signaling["Calcium Signaling"] -->|"interacts"| Phagocytosis["Phagocytosis"]
    Calcium_Signaling["Calcium Signaling"] -->|"interacts"| Apoptosis["Apoptosis"]
    Calcium_Signaling["Calcium Signaling"] -->|"interacts"| Akt["Akt"]
    Calcium_Signaling["Calcium Signaling"] -->|"interacts"| Pi3K["Pi3K"]
    Calcium_Signaling["Calcium Signaling"] -->|"interacts"| Blood_Brain_Barrier["Blood-Brain Barrier"]
    JUN["JUN"] -->|"regulates"| Calcium_Signaling["Calcium Signaling"]
    MCOLN1["MCOLN1"] -->|"regulates"| Calcium_Signaling["Calcium Signaling"]
    BANG["BANG"] -->|"activates"| Calcium_Signaling["Calcium Signaling"]
    GPR37["GPR37"] -->|"activates"| Calcium_Signaling["Calcium Signaling"]
    style Calcium_Signaling fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (87)

Target	Relation	Type	Str
Macrophage Phagocytosis	mediates	process	0.90
Neuroregeneration	regulates	process	0.90
Neuronal Cell Death	mediates	process	0.85
Neuronal Dendrites	involved_in	cell_type	0.80
Phagocytosis	interacts_with	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Akt	interacts_with	pathway	0.55
Pi3K	interacts_with	pathway	0.55
Blood-Brain Barrier	interacts_with	pathway	0.55
Proteins	regulates	protein	0.50
IL-17	expressed_in	concept	0.50
disease	associated_with	disease	0.50
PARKINSON'S	associated_with	concept	0.50
ALZHEIMER'S	associated_with	concept	0.50
disease	expressed_in	disease	0.50
ALZHEIMER'S	expressed_in	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
Fibroblast	regulates	cell_type	0.50
Microglia	activates	cell_type	0.50
Neutrophil	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Astrocyte	regulates	cell_type	0.50
Neuron	regulates	cell_type	0.50
Neuron	contributes_to	cell_type	0.50
Dopaminergic	contributes_to	cell_type	0.50
Astrocyte	activates	cell_type	0.50
Neuron	associated_with	cell_type	0.50
Oligodendrocyte	activates	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Neutrophil	associated_with	cell_type	0.50
Dendritic Cell	associated_with	cell_type	0.50
Cardiomyocyte	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Astrocyte	expressed_in	cell_type	0.50

Incoming (493)

Source	Relation	Type	Str
MERCS	regulates	process	0.90
ANNEXINS	involved_in	protein	0.90
Er-Plasma Membrane Junctions	mediates	mechanism	0.90
ER-Mitochondria Contact Sites	involved_in	mechanism	0.90
APOE	inhibits	gene	0.90
ER-Plasma Membrane Junctions	mediates	mechanism	0.85
P2 RECEPTORS	regulates	receptor	0.85
Voltage-Gated Calcium Channels	regulates	protein	0.80
Als	regulates	disease	0.80
Alzheimer	therapeutic_target	disease	0.80
APOPTOSIS	therapeutic_target	gene	0.80
AQP4	involved_in	protein	0.75
GLUCOCORTICOID RECEPTOR	regulates	receptor	0.75
Neurodegeneration	regulates	disease	0.70
AUTOPHAGY	activates	gene	0.70
INFLAMMATION	regulates	gene	0.70
MITOPHAGY	regulates	gene	0.70
NEURODEGENERATION	regulates	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.70
Als	therapeutic_target	disease	0.70
Inflammation	regulates	disease	0.65
JUN	regulates	gene	0.60
MCOLN1	regulates	gene	0.60
BANG	activates	gene	0.60
GPR37	activates	gene	0.60
CALB1	associated_with	gene	0.60
KCNN3	associated_with	gene	0.60
GRIN2B	associated_with	gene	0.60
CAV1	associated_with	gene	0.60
GAIN	associated_with	gene	0.60
CACNA1C	associated_with	gene	0.60
GENES	regulates	gene	0.60
Ms	regulates	disease	0.60
Inflammation	activates	disease	0.60
Als	activates	disease	0.60
Ms	activates	disease	0.60
PI3K	activates	gene	0.60
CTSD	regulates	gene	0.60
FGF19	regulates	gene	0.60
AKT	activates	gene	0.60
Depression	activates	disease	0.60
PLCB4	activates	gene	0.60
ADAM10	activates	gene	0.60
Aging	therapeutic_target	disease	0.60
JUN	associated_with	gene	0.60
MCOLN1	associated_with	gene	0.60
LC3B	inhibits	gene	0.60
LAMP2A	inhibits	gene	0.60
CD4	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Layer V excitatory neurons show selectively enhanced vulnera	0.510	Alzheimer's disease	SEA-AD Single-Cell Analysis: Cell-Type V

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (1)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Social Processing in the Amygdala: Single-Nucleus RNA-Sequencing Reveals Distinc [PMID:41727617]	Dwortz MF, Hofmann HA, Curley JP	Res Sq	2026	0

Calcium Signaling

Understanding Entity Pages

Summary

Wiki Pages (21)