gene

amyloid aggregation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about amyloid aggregation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

66Connections

0Hypotheses

0Analyses

0Outgoing

50Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	AMYLOID
Full Name	amyloid aggregation
Function	is a critical molecular neuroimaging biomarker that visualizes fibrillar amyloid-beta (Aβ) plaque burden in vivo.
GeneCards	AMYLOID
Human Protein Atlas	AMYLOID
Associated Diseases	AQP4, astrocytes, MAPT, PSEN1, APP, APOE
KG Connections	65 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    APP["APP"] -->|"associated"| amyloid_aggregation["amyloid aggregation"]
    style APP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    oxidative_stress_response["oxidative stress response"] -->|"mediates"| amyloid_aggregation["amyloid aggregation"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    microglia["microglia"] -->|"activates"| amyloid_aggregation["amyloid aggregation"]
    style microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    astrocytes["astrocytes"] -->|"associated"| amyloid_aggregation["amyloid aggregation"]
    style astrocytes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREM2["TREM2"] -->|"regulates"| amyloid_aggregation["amyloid aggregation"]
    style TREM2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style amyloid_aggregation fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (66)

Source	Relation	Type	Str
APP	associated_with	gene	0.80
oxidative stress response	mediates	pathway	0.80
microglia	activates	cell_type	0.80
astrocytes	associated_with	cell_type	0.70
microglia	inhibits	cell_type	0.70
TREM2	regulates	gene	0.70
microglia	regulates	cell_type	0.70
BACE1	regulates	gene	0.70
TREM2	interacts_with	gene	0.70
microglia	interacts_with	cell_type	0.70
astrocytes	regulates	cell_type	0.70
AQP4	associated_with	gene	0.60
BMAL1	activates	gene	0.60
TREM2	inhibits	gene	0.60
MAPT	associated_with	gene	0.60
HDAC	inhibits	gene	0.60
PSEN1	associated_with	gene	0.60
APP	inhibits	gene	0.60
CD68	inhibits	gene	0.60
APOE4	interacts_with	gene	0.60
APOE	associated_with	gene	0.60
APOE4	associated_with	gene	0.60
PI3K	regulates	gene	0.60
PI3K-AKT-mTOR signaling	mediates	pathway	0.60
ISG	activates	gene	0.60
SREBP2	activates	gene	0.60
BACE1	activates	gene	0.60
CYP46A1	activates	gene	0.60
ABCA1	activates	gene	0.60
GSK3B	activates	gene	0.60
TREM2	activates	gene	0.60
Wnt signaling	mediates	pathway	0.60
GFAP	associated_with	gene	0.60
IBA1	associated_with	gene	0.60
microglia	associated_with	cell_type	0.60
DNAJB6	inhibits	gene	0.60
DNAJB6	interacts_with	gene	0.60
APOE3	associated_with	gene	0.60
C1QB	interacts_with	gene	0.60
APP	implicated_in	gene	0.60
SIRT2	protects_against	gene	0.60
APP	protects_against	gene	0.60
microglia	protects_against	cell_type	0.60
BIN1	associated_with	gene	0.60
BIN1	interacts_with	gene	0.60
oligodendrocytes	interacts_with	cell_type	0.60
NGF	associated_with	gene	0.60
INPP5D	activates	gene	0.60
LGALS3	regulates	gene	0.60
APOE4	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

amyloid aggregation

Understanding Entity Pages

Wiki Pages (20)

Alpha-Synuclein Pathology

Alzheimer's Disease

Mitophagy Pathway in Neurodegeneration

Infectious Triggers in Alzheimer's Disease

Clinical Trials Dashboard

Machado-Joseph Disease (Spinocerebellar Ataxia Type 3)

Experiment Prioritization Index — Neurodegeneration

Amyloid-Beta Aggregation and Plaque Formation

Amyloid-beta Fibril Formation Pathway

Alzheimer's Drug Discovery Foundation (ADDF)

Neurogenesis and Neurodegeneration

CNTFR Gene

Gamma-Secretase Complex (γ-Secretase)

dementia-discovery-fund

Endosomal Sorting Defects in Neurodegeneration

Blood-Based Biomarkers for Neurodegeneration

alpha-synuclein-seed-amplification

Tricaprilin Phase 3 ALTER-AD Study (NCT05809908)