| Gene Symbol | PLCB4 |
| Full Name | Phospholipase C Beta 4 |
| Chromosome | 20p12.3 |
| Protein Type | Receptor |
| Function | Upon receptor activation, the Gαq subunit activates PLCB4, which then hydrolyzes PIP2 in the plasma membrane |
| Primary Expression | Purkinje cells, mediating signaling from: - Metabotropic glutamate receptors (mGluR1): Critical for cerebellar LTD - Muscarinic acetylcholine re |
| Molecular Weight | 135 kDa |
| Amino Acids | 175 aa |
| Exons | 33 |
| Pathways | Calcium Signaling, Long-Term Potentiation, amyloid aggregation, calcium signaling, synaptic plasticity |
| Ensembl ID | ENSG00000151327 |
| GeneCards | PLCB4 |
| Human Protein Atlas | PLCB4 |
| DAG | Activates protein kinase C (PKC) isoforms |
| IP3 | Binds IP3 receptors on the endoplasmic reticulum, triggering calcium release |
| Associated Diseases | Alzheimer |
| Interactions | ADAM10 |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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