gene

PLN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

6Outgoing

2Incoming

Summary

PLN Gene

View on Wiki →

🧬 Gene Info

Gene Symbol	PLN
Full Name	Phospholamban
Chromosome	6q22.1
Function	Phospholamban regulates calcium reuptake into the sarcoplasmic reticulum:
Primary Expression	cardiac and skeletal muscle, but calcium handling mechanisms involving PLN are also important in neurons where calcium dysregulat
UniProt ID	P26678
NCBI Gene ID	5350
Ensembl ID	ENSG00000160072
OMIM	172090
GeneCards	PLN
Human Protein Atlas	PLN
Encoded Protein	Phospholamban
Associated Diseases	neurodegeneration
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PLN — AlphaFold P26678 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLN["<b>PLN</b>"]
    Heart_Failure{"Heart Failure"}
    PLN -->|"therapeutic target"| Heart_Failure
    Ms{"Ms"}
    PLN -->|"therapeutic target"| Ms
    TPM1["TPM1"]
    PLN -->|"therapeutic target"| TPM1
    GENE_MUTATIONS["GENE MUTATIONS"]
    PLN -->|"therapeutic target"| GENE_MUTATIONS
    LMNA["LMNA"]
    PLN -->|"therapeutic target"| LMNA
    ATF4["ATF4"]
    PLN -->|"therapeutic target"| ATF4
    neurodegeneration["neurodegeneration"]
    PLN -->|"implicated in"| neurodegeneration
    PHGDH["PHGDH"]
    PHGDH -->|"therapeutic target"| PLN
    LAMA2["LAMA2"]
    LAMA2 -->|"therapeutic target"| PLN
    style PLN fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Heart Failure	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
TPM1	therapeutic_target	gene	0.60
LMNA	therapeutic_target	gene	0.60
ATF4	therapeutic_target	gene	0.60
GENE MUTATIONS	therapeutic_target	gene	0.60

Incoming (2)

Source	Relation	Type	Str
LAMA2	therapeutic_target	gene	0.60
PHGDH	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PLN