TPM1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TPM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TPM1 is a gene implicated in neurodegeneration research. Key relationships include: inhibits, therapeutic target, regulates. Associated with Als, Cardiac, Fibrosis. Connected to 23 entities in the SciDEX knowledge graph.

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graph TD
    TPM1["<b>TPM1</b>"]
    Fibrosis{"Fibrosis"}
    TPM1 -->|"inhibits"| Fibrosis
    Als{"Als"}
    TPM1 -->|"inhibits"| Als
    Cardiac{"Cardiac"}
    TPM1 -->|"regulates"| Cardiac
    Ischemia{"Ischemia"}
    TPM1 -->|"regulates"| Ischemia
    Heart_Failure{"Heart Failure"}
    TPM1 -->|"therapeutic target"| Heart_Failure
    Ms{"Ms"}
    TPM1 -->|"therapeutic target"| Ms
    APOPTOSIS["APOPTOSIS"]
    TPM1 -->|"inhibits"| APOPTOSIS
    AUTOPHAGY["AUTOPHAGY"]
    TPM1 -->|"regulates"| AUTOPHAGY
    BCL_2["BCL-2"]
    TPM1 -->|"inhibits"| BCL_2
    IDH3A["IDH3A"]
    TPM1 -->|"inhibits"| IDH3A
    Apoptosis(["Apoptosis"])
    TPM1 -->|"inhibits"| Apoptosis
    Autophagy(["Autophagy"])
    TPM1 -->|"regulates"| Autophagy
    BNIP3["BNIP3"]
    BNIP3 -->|"inhibits"| TPM1
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"inhibits"| TPM1
    PHGDH["PHGDH"]
    PHGDH -->|"therapeutic target"| TPM1
    LAMA2["LAMA2"]
    LAMA2 -->|"therapeutic target"| TPM1
    PLN["PLN"]
    PLN -->|"therapeutic target"| TPM1
    style TPM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0