LAMA2

Understanding Entity Pages

This page aggregates everything SciDEX knows about LAMA2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

LAMA2 encodes laminin alpha-2, a critical extracellular matrix protein in skeletal muscle, peripheral nerve, and brain. Mutations cause congenital muscular dystrophy and merosin-deficient muscular dystrophy.

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graph TD
    LAMA2["<b>LAMA2</b>"]
    Heart_Failure{"Heart Failure"}
    LAMA2 -->|"therapeutic target"| Heart_Failure
    Ms{"Ms"}
    LAMA2 -->|"therapeutic target"| Ms
    LAMA2 -->|"regulates"| Ms
    PLN["PLN"]
    LAMA2 -->|"therapeutic target"| PLN
    TPM1["TPM1"]
    LAMA2 -->|"therapeutic target"| TPM1
    GENE_MUTATIONS["GENE MUTATIONS"]
    LAMA2 -->|"therapeutic target"| GENE_MUTATIONS
    LMNA["LMNA"]
    LAMA2 -->|"therapeutic target"| LMNA
    ATF4["ATF4"]
    LAMA2 -->|"therapeutic target"| ATF4
    BCL2L13["BCL2L13"]
    LAMA2 -->|"regulates"| BCL2L13
    NF2["NF2"]
    LAMA2 -->|"regulates"| NF2
    APOPTOSIS["APOPTOSIS"]
    LAMA2 -->|"regulates"| APOPTOSIS
    Apoptosis(["Apoptosis"])
    LAMA2 -->|"regulates"| Apoptosis
    PHGDH["PHGDH"]
    PHGDH -->|"therapeutic target"| LAMA2
    style LAMA2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0