Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POU5F1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
POU5F1 (OCT4) is a key transcription factor for maintaining pluripotency in embryonic stem cells and cellular reprogramming. Important in developmental biology and regenerative medicine.
| Gene Symbol | POU5F1 |
| Full Name | POU Class 5 Homeobox 1 (OCT4) |
| Chromosome | 6p21.33 |
| Protein Type | Transcription Factor |
| Function | is a key transcription factor that plays a fundamental role in maintaining cellular pluripotency—the ability of a cell to differentiate into any cell type in the body. |
| Molecular Weight | 38.5 kDa |
| Amino Acids | 360 aa |
| Pathways | Pluripotency |
| UniProt ID | Q9U5J1 |
| NCBI Gene ID | 27008 |
| Ensembl ID | ENSG00000212749 |
| GeneCards | POU5F1 |
| Human Protein Atlas | POU5F1 |
| Octamer motif recognition | The canonical "ATTTGCAT" sequence |
| Composite elements | Additional sequences that modify binding |
| Associated Diseases | Cancer, Developmental Disorders, Infertility |
| Interactions | KLF4, SOX2, OCT4, DNA, AND, App |
| KG Connections | 21 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
POU5F1["<b>POU5F1</b>"]
KLF4["KLF4"]
POU5F1 -->|"activates"| KLF4
SOX2["SOX2"]
POU5F1 -->|"activates"| SOX2
DNA["DNA"]
POU5F1 -->|"activates"| DNA
AND["AND"]
POU5F1 -->|"activates"| AND
OCT4["OCT4"]
POU5F1 -->|"activates"| OCT4
Stem_Cell["Stem Cell"]
POU5F1 -->|"expressed in"| Stem_Cell
neurodegeneration["neurodegeneration"]
POU5F1 -->|"implicated in"| neurodegeneration
SOX2 -->|"activates"| POU5F1
KLF4 -->|"activates"| POU5F1
OCT4 -->|"activates"| POU5F1
DNA -->|"activates"| POU5F1
style POU5F1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Embryonic Stem Cells | expressed_in | cell_type | 0.90 |
| Pluripotency | involved_in | process | 0.90 |
| Transcription | regulates | process | 0.85 |
| Alzheimer'S Disease | involved_in | disease | 0.80 |
| KLF4 | activates | gene | 0.60 |
| SOX2 | activates | gene | 0.60 |
| OCT4 | activates | gene | 0.60 |
| DNA | activates | gene | 0.60 |
| Stem Cell | activates | cell_type | 0.60 |
| AND | activates | gene | 0.60 |
| App | activates | protein | 0.60 |
| epigenetic regulation | participates_in | pathway | 0.60 |
| Stem Cell | expressed_in | cell_type | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||