Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HDAC9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Histone Deacetylase 9 - class IIa HDAC involved in epigenetic regulation, synaptic plasticity, and neurodegeneration
| Gene Symbol | HDAC9 |
| Full Name | Histone Deacetylase 9 |
| Chromosome | 7p21.1 |
| Function | encodes a class IIa histone deacetylase that plays crucial roles in epigenetic regulation, transcriptional control, and cellular signaling in the brain. |
| Primary Expression | Brain, heart, skeletal muscle |
| Molecular Weight | 110 kDa |
| UniProt ID | Q9UKV0 |
| NCBI Gene ID | 9734 |
| Ensembl ID | ENSG00000048828 |
| OMIM | 606365 |
| GeneCards | HDAC9 |
| Human Protein Atlas | HDAC9 |
| Associated Diseases | Als, Coronary Artery Disease, Inflammation, Stroke |
| Interactions | NRF2, KDR, POU5F1, INFLAMMATION, NANOG, HDAC5 |
| KG Connections | 38 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HDAC9["<b>HDAC9</b>"]
Stroke{"Stroke"}
HDAC9 -->|"activates"| Stroke
Ms{"Ms"}
HDAC9 -->|"therapeutic target"| Ms
Atherosclerosis{"Atherosclerosis"}
HDAC9 -->|"activates"| Atherosclerosis
Inflammation{"Inflammation"}
HDAC9 -->|"activates"| Inflammation
INFLAMMATION["INFLAMMATION"]
HDAC9 -->|"activates"| INFLAMMATION
neurodegeneration["neurodegeneration"]
HDAC9 -->|"implicated in"| neurodegeneration
MEF2D["MEF2D"]
MEF2D -->|"associated with"| HDAC9
style HDAC9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| epigenetic regulation | participates_in | pathway | 0.80 |
| Stroke | activates | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Atherosclerosis | activates | disease | 0.65 |
| Inflammation | activates | disease | 0.65 |
| Coronary Artery Disease | associated_with | disease | 0.65 |
| Stroke | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Inflammation | causes | disease | 0.65 |
| ALDH2 | associated_with | gene | 0.60 |
| APOE | associated_with | gene | 0.60 |
| NRF2 | activates | gene | 0.60 |
| KDR | activates | gene | 0.60 |
| POU5F1 | activates | gene | 0.60 |
| INFLAMMATION | activates | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| STROKE | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| RUNX2 | associated_with | gene | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| NANOG | activates | gene | 0.60 |
| NRF2 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MEF2D | associated_with | gene | 0.90 |
| MMP12 | associated_with | gene | 0.60 |
| ATM | associated_with | gene | 0.60 |
| HDAC5 | associated_with | gene | 0.60 |
| HDAC5 | inhibits | gene | 0.60 |
| HDAC5 | activates | gene | 0.60 |
| HDAC1 | regulates | gene | 0.60 |
| HDAC3 | regulates | gene | 0.60 |
| PERICYTE | associated_with | gene | 0.60 |
| INFLAMMATION | causes | gene | 0.60 |
| METTL3 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| HDAC | activates | gene | 0.60 |
| HDAC5 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.578
neurodegeneration | 2026-04-14 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||