Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP2R2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PPP2R2A |
| Full Name | Protein Phosphatase 2 Regulatory Subunit B55 Alpha |
| Chromosome | 8p21.2 |
| Function | is a hallmark of Alzheimer's disease and other neurodegenerative disorders, making it a critical therapeutic target [2](https://doi. |
| Molecular Weight | ~52 kDa |
| Amino Acids | 447 aa |
| Pathways | Mapk |
| UniProt ID | P63151 |
| NCBI Gene ID | 5520 |
| Ensembl ID | ENSG00000156535 |
| OMIM | 601728 |
| GeneCards | PPP2R2A |
| Human Protein Atlas | PPP2R2A |
| Feature | Value |
| Protein Length | 447 amino acids |
| Associated Diseases | neurodegeneration |
| Interactions | CAV2, PIK3C3, ERK, CANCER |
| KG Connections | 13 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
PPP2R2A["<b>PPP2R2A</b>"]
Als{"Als"}
PPP2R2A -->|"activates"| Als
Aging{"Aging"}
PPP2R2A -->|"regulates"| Aging
Cancer{"Cancer"}
PPP2R2A -->|"regulates"| Cancer
CANCER["CANCER"]
PPP2R2A -->|"regulates"| CANCER
CAV2["CAV2"]
PPP2R2A -->|"activates"| CAV2
PIK3C3["PIK3C3"]
PPP2R2A -->|"activates"| PIK3C3
Mapk(["Mapk"])
PPP2R2A -->|"activates"| Mapk
neurodegeneration["neurodegeneration"]
PPP2R2A -->|"implicated in"| neurodegeneration
AGING["AGING"]
AGING -->|"regulates"| PPP2R2A
style PPP2R2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity