protein

PRDX1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRDX1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Peroxiredoxins represent an evolutionarily conserved family of peroxidases that were first discovered in yeast and subsequently characterized across all kingdoms of life.

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🔬 Protein Info

Gene Symbol	PRDX1PROTEIN
Full Name	Peroxiredoxin 1
Protein Family	Peroxiredoxin family (2-Cys typical)
Function	is a member of the peroxiredoxin family of antioxidant proteins that catalyze the reduction of hydrogen peroxide (H₂O₂), organic hydroperoxides, and peroxynitrite.
Primary Expression	Ubiquitous, highest in brain, liver, kidney
Molecular Weight	22 kDa (199 amino acids)
Amino Acids	199 aa
UniProt ID	Q06830
GeneCards	PRDX1PROTEIN
Human Protein Atlas	PRDX1PROTEIN
N-terminal region	Contains the resolving cysteine (Cys⁵¹) critical for catalytic activity
C-terminal region	Harbors the peroxidatic cysteine (Cys¹⁷²) that initiates the peroxide reduction reaction
Conserved FFYPGW motif	Located in the active site pocket, essential for substrate binding
Decameric assembly	At high concentrations, PRDX1 dimers associate into ring-like decamers (10-mers) that enhance its chaperone activity
Associated Diseases	Lymphoma, Tumor
Known Drugs/Compounds	Lipopolysaccharide, LPS
Interactions	AKT, AND, APOPTOSIS, ARHGEF2, AUTOPHAGY, BECN1
KG Connections	175 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PRDX1PROTEIN — AlphaFold Q06830 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PRDX1 (Peroxiredoxin 1)

protein · 2419 words

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Pathway Diagram

graph TD
    PRDX1PROTEIN["PRDX1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PRDX1PROTEIN -->|"implicated_in"| neurodegeneration
    style PRDX1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PRDX1PROTEIN in their description or question text

No additional research found