gene

arhgef2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about arhgef2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections

0Hypotheses

0Analyses

6Outgoing

8Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	ARHGEF2
Full Name	Rho Guanine Nucleotide Exchange Factor 2
Chromosome	1q22
Function	ARHGEF2 encodes a Rho GEF that activates Rho GTPases, primarily RhoA, but also Rac1 and Cdc42.
Molecular Weight	220 kDa
Amino Acids	736 aa
Exons	33
UniProt ID	Q9Y5S5
NCBI Gene ID	9199
Ensembl ID	ENSG00000116584
OMIM	607560
GeneCards	ARHGEF2
Human Protein Atlas	ARHGEF2
Associated Diseases	Intellectual disability, Midbrain-hindbrain malformation, neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: arhgef2 — AlphaFold Q9Y5S5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (8)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ARHGEF2["ARHGEF2"]
    ARHGEF2 -->|"activates"| RhoA["RhoA"]
    ARHGEF2 -->|"causes"| Intellectual_disability["Intellectual disability"]
    ARHGEF2 -->|"causes"| Midbrain_hindbrain_malformatio["Midbrain-hindbrain malformation"]
    ARHGEF2 -->|"activates"| Rac1["Rac1"]
    ARHGEF2 -->|"regulates"| Macropinocytosis["Macropinocytosis"]
    ARHGEF2 -->|"interacts"| CaMKK2["CaMKK2"]
    ARHGEF2 -->|"activates"| AMPK["AMPK"]
    ARHGEF2 -->|"activates"| MAPK_signaling["MAPK signaling"]
    PRDX1["PRDX1"] -->|"interacts"| ARHGEF2
    LMNA["LMNA"] -->|"interacts"| ARHGEF2
    IRF2BP2["IRF2BP2"] -->|"interacts"| ARHGEF2
    SQSTM1["SQSTM1"] -->|"interacts"| ARHGEF2
    NPM1["NPM1"] -->|"interacts"| ARHGEF2
    TPM3["TPM3"] -->|"interacts"| ARHGEF2
    RNA["RNA"] -->|"regulates"| ARHGEF2

Outgoing (36)

Target	Relation	Type	Str
LMNA	associated_with	gene	0.50
NPM1	associated_with	gene	0.50
SQSTM1	associated_with	gene	0.50
TPM3	associated_with	gene	0.50
NTRK1	associated_with	protein	0.50
PRDX1	associated_with	protein	0.50

Incoming (8)

Source	Relation	Type	Str
PRDX1	interacts_with	gene	0.60
LMNA	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NPM1	interacts_with	gene	0.60
TPM3	interacts_with	gene	0.60
IRF2BP2	interacts_with	gene	0.60
RNA	regulates	gene	0.60
benchmark_ot_ad_answer_key:ARHGEF2	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

arhgef2

Understanding Entity Pages

Wiki Pages (8)

ntrk1

ARHGEF2 Protein (LARG)

Intellectual Disability

ARHGEF28 — Rho Guanine Nucleotide Exchange Factor 28

P-Body (Processing Body) Pathway in Neurodegeneration

ARHGEF2 Gene