Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB5C: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB5C is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, regulates, activates. Associated with Als, Carcinoma, Hepatocellular Carcinoma. Connected to 17 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB5C |
| Full Name | RAB5C, Member RAS Oncogene Family |
| Chromosome | 17q21.2 |
| Function | encodes a member of the Rab family of small GTPases, which are essential regulators of intracellular membrane trafficking. |
| Primary Expression | Ubiquitous, high in brain |
| Amino Acids | 215 aa |
| Pathways | PI3K |
| UniProt ID | RAB5A |
| NCBI Gene ID | 11021 |
| Ensembl ID | ENSG00000169018 |
| OMIM | 602377 |
| GeneCards | RAB5C |
| Human Protein Atlas | RAB5C |
| Associated Diseases | neurodegeneration |
| Interactions | MFN1, P62, FERROPTOSIS |
| KG Connections | 22 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RAB5C["<b>RAB5C</b>"]
Ms{"Ms"}
RAB5C -->|"interacts with"| Ms
MFN2["MFN2"]
RAB5C -->|"regulates"| MFN2
MFN1["MFN1"]
RAB5C -->|"interacts with"| MFN1
AUTOPHAGY["AUTOPHAGY"]
RAB5C -->|"regulates"| AUTOPHAGY
Autophagy(["Autophagy"])
RAB5C -->|"regulates"| Autophagy
neurodegeneration["neurodegeneration"]
RAB5C -->|"implicated in"| neurodegeneration
style RAB5C fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| mitochondrial homeostasis | modulates | process | 0.80 |
| AUTOPHAGY | regulates | gene | 0.70 |
| Autophagy | regulates | pathway | 0.70 |
| Ms | interacts_with | disease | 0.65 |
| Tumor | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.65 |
| MFN2 | regulates | gene | 0.60 |
| MFN1 | interacts_with | gene | 0.60 |
| P62 | activates | gene | 0.60 |
| FERROPTOSIS | activates | gene | 0.60 |
| Lysosomal Degradation | activates | pathway | 0.60 |
| Ferroptosis | activates | pathway | 0.60 |
| Lipid Metabolism | therapeutic_target | pathway | 0.60 |
| RAS | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MFN1 | interacts_with | gene | 0.60 |
| MFN2 | regulates | gene | 0.60 |
| ACETYL-COA | therapeutic_target | gene | 0.60 |
| LYSOSOME | regulates | gene | 0.60 |
| MITOCHONDRIA | regulates | gene | 0.60 |
| AND | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||