gene 1,852 words KG: RAB5A 2026-03-22
kind:genesection:genesstate:published
Contents

RAB5A — Ras-Related Protein Rab-5A

🧬 Gene Info
Gene SymbolRAB5A
Full NameRas-Related Protein Rab-5A
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight24 kDa
Amino Acids218 aa
PathwaysMAPK signaling
Ensembl IDENSG00000108510
GeneCardsRAB5A
Human Protein AtlasRAB5A
EEA1Master organizer of early endosome docking
Rabenosyn-5Cargo sorting and transport
FYCO1Lysosomal trafficking and autophagosome-lysosome fusion
P38αMAPK signaling scaffold
SAND-1/Mon1HOPS complex recruitment
Associated DiseasesALS
InteractionsNEURODEGENERATIVE DISEASES
KG Connections32 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (6)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.68
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.51
Lysosomal Enzyme Trafficking Correction
Score: 0.49
Mitochondrial-Lysosomal Contact Site Engineering
Score: 0.43
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.42

Related Analyses (7)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · archived
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived

See Also (15)

IGF2R Protein
protein · KG edge: therapeutic_target
Packard Center for ALS Research
institution · KG edge: associated_with
RAB8A — RAB8A, Member RAS Oncogene Family
gene · KG edge: therapeutic_target
RAB5A Gene
gene · KG edge: associated_with
RAB4B Gene
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RAB5A associated_with RAB11B
RAB5A associated_with RAB10
RAB5A associated_with RAB3A
RAB5A associated_with RAB5
RAB5A associated_with RAB27B
RAB5A therapeutic_target HSPA1A
RAB5A therapeutic_target RAB8A
RAB5A therapeutic_target CANX
RAB5A therapeutic_target HSPA5
RAB5A associated_with RAB3B