| Gene Symbol | RAB5PROTEIN |
| Protein Family | Rab GTPase |
| Function | is a member of the Rab GTPase family that functions as a critical regulator of early endosomal trafficking and membrane organization. |
| Primary Expression | Ubiquitous, highest in brain, lung, kidney |
| Subcellular Localization | the cytoplasmic face of early endosomes, where it orchestrates the temporal and spatial dynamics of endocytic traffickin |
| Molecular Weight | ~23.5 kDa |
| UniProt ID | P20339 (RAB5A), Q13584 (RAB5B), Q9H0U3 (RAB5C) |
| GeneCards | RAB5PROTEIN |
| Human Protein Atlas | RAB5PROTEIN |
| Gene Name | RAB5A, RAB5B, RAB5C |
| Structure | Switch I/II regions, GxxxxGKST motif, NKXD motif |
| Post-translational | Geranylgeranylation at C-terminal cysteines |
| Associated Diseases | Aging, Als, Alzheimer, Amyotrophic Lateral Sclerosis, Ataxia, Dementia |
| Interactions | C1Q, ATG9A, RAB11, C1Q/C3, RAB7, COMPLEMENT |
| KG Connections | 393 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |