protein

RECQL4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RECQL4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

6Outgoing

4Incoming

0Experiments

0Debates

Summary

RECQL4 is a protein involved in neurodegeneration research. Key relationships include: activates, associated with, implicated in. Associated with Carcinoma, Ms, Tumor. Connected to 11 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🔬 Protein Info

Gene Symbol	RECQL4
Full Name	RECQ DNA Helicase Like 4
Chromosome	8q24.3
Protein Family	RecQ DNA Helicase Family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Skeletal muscle, Bone marrow, Brain (cerebellum, cortex)
Subcellular Localization	Nucleus, Mitochondria
Molecular Weight	120 kDa
Pathways	Nf-Κb
UniProt ID	Q9U143
Ensembl ID	ENSG00000015171
GeneCards	RECQL4
Human Protein Atlas	RECQL4
Associated Diseases	Tumor
Interactions	G3BP1, GAIN, GENES, NF-ΚB, YBX1
KG Connections	10 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: RECQL4 — AlphaFold Q9U143 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RECQL4 — RECQ DNA Helicase Like 4

gene · 551 words

→

RECQL4 Protein

protein · 543 words

→

Pathway Diagram

graph TD
    RECQL4["RECQL4"]
    Carcinoma{"Carcinoma"}
    RECQL4 -->|"activates"| Carcinoma
    Tumor{"Tumor"}
    RECQL4 -->|"associated with"| Tumor
    Ms{"Ms"}
    RECQL4 -->|"activates"| Ms
    YBX1["YBX1"]
    RECQL4 -->|"activates"| YBX1
    Nf__b(["Nf-Kappab"])
    RECQL4 -->|"activates"| Nf__b
    NF__B["NF-KappaB"]
    RECQL4 -->|"activates"| NF__B
    neurodegeneration["neurodegeneration"]
    RECQL4 -->|"implicated in"| neurodegeneration
    GAIN["GAIN"]
    GAIN -->|"activates"| RECQL4
    GENES["GENES"]
    GENES -->|"activates"| RECQL4
    DNA["DNA"]
    DNA -->|"associated with"| RECQL4
    G3BP1["G3BP1"]
    G3BP1 -->|"activates"| RECQL4
    style RECQL4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (6)

Target	Relation	Type	Str
Carcinoma	activates	disease	0.65
Tumor	associated_with	disease	0.65
Ms	activates	disease	0.65
YBX1	activates	gene	0.60
Nf-Κb	activates	pathway	0.60
NF-ΚB	activates	gene	0.60

Incoming (4)

Source	Relation	Type	Str
GAIN	activates	gene	0.60
G3BP1	activates	gene	0.60
GENES	activates	gene	0.60
DNA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RECQL4 in their description or question text

No additional research found