Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RNF20: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RNF20 |
| Chromosome | 9q34.3 |
| Protein Type | Ligase |
| Function | RNF20 (Ring Finger Protein 20) is an E3 ubiquitin-protein ligase encoded by the RNF20 gene located on chromosome 9q34.3[@kim2009] |
| UniProt ID | Q5VTL2 |
| Ensembl ID | ENSG00000146727 |
| GeneCards | RNF20 |
| Human Protein Atlas | RNF20 |
| H2B ubiquitination | Catalyzes H2B K120ub1, a modification associated with active transcription[@minsky2008] |
| Transcriptional elongation | H2B-K120ub1 facilitates RNA Pol II passage through chromatin[@pavri2006] |
| DNA damage response | H2B ubiquitination promotes homologous recombination repair[@moyal2011] |
| p53 regulation | RNF20 modulates p53 activity through H2B ubiquitination[@shema2008] |
| Colorectal cancer | RNF20 frequently downregulated; tumor suppressor function[@tarcic2012] |
| Breast cancer | RNF20 expression correlates with prognosis; loss promotes metastasis[@zhang2015] |
| Gastric cancer | RNF20 reduced in aggressive subtypes[@liu2015] |
| Associated Diseases | neurodegeneration |
| Interactions | VEGFA, SGMS1, PPAR, NCOR1, CRLS1, PIKFYVE |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
RNF20(["RNF20"])
Als["Als"]
UBIQUITIN(["UBIQUITIN"])
T_Cell["/"T Cell"/"]
PPAR(["PPAR"])
NCOR1(["NCOR1"])
neurodegeneration["neurodegeneration"]
RNF20 -->|"activates"| Als
RNF20 -->|"regulates"| Als
RNF20 -->|"associated with"| UBIQUITIN
RNF20 -->|"activates"| T_Cell
RNF20 -->|"regulates"| UBIQUITIN
PPAR -->|"activates"| RNF20
NCOR1 -->|"activates"| RNF20
RNF20 -->|"implicated in"| neurodegeneration
style RNF20 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| Als | activates | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| UBIQUITIN | associated_with | gene | 0.60 |
| UBIQUITIN | regulates | gene | 0.60 |
| VEGFA | activates | gene | 0.60 |
| VEGF | regulates | gene | 0.60 |
| SGMS1 | activates | gene | 0.60 |
| Notch signaling | participates_in | pathway | 0.60 |
| T Cell | activates | cell_type | 0.60 |
| ubiquitin-proteasome | participates_in | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||