concept

PIKFYVE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PIKFYVE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

133Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PIKFYVE
Key Genes/Proteins	MCOLN1, PtdIns(3,5)P2, LRRK2, AMPK
Related Diseases	ALS, Disease Progression, AMYOTROPHIC LATERAL SCLEROSIS, Als
Related Pathways	Protein Clearance
Linked Hypotheses	2 hypotheses

Wiki Pages (7)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PIKFYVE["PIKFYVE"]
    PIKFYVE -->|"targets"| ALS["ALS"]
    PIKFYVE -->|"regulates"| MCOLN1["MCOLN1"]
    PIKFYVE -->|"produces"| PtdIns_3_5_P2["PtdIns(3,5)P2"]
    PIKFYVE -->|"involved_in"| Motor_Neuron_Degeneration["Motor Neuron Degeneration"]
    PIKFYVE -->|"inhibits"| Als["Als"]
    PIKFYVE -->|"inhibits"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    PIKFYVE -->|"inhibits"| Ms["Ms"]
    PIKFYVE -->|"activates"| Parkinson["Parkinson"]
    AMPK["AMPK"] -->|"activates"| PIKFYVE
    C9ORF72["C9ORF72"] -->|"inhibits"| PIKFYVE
    ALS -->|"inhibits"| PIKFYVE
    GABARAP["GABARAP"] -->|"activates"| PIKFYVE
    FUS["FUS"] -->|"inhibits"| PIKFYVE
    ENDOSOMES["ENDOSOMES"] -->|"activates"| PIKFYVE
    PTEN["PTEN"] -->|"activates"| PIKFYVE
    MOTOR_NEURONS["MOTOR NEURONS"] -->|"inhibits"| PIKFYVE
    UBIQUITIN["UBIQUITIN"] -->|"inhibits"| PIKFYVE
    TARDBP["TARDBP"] -->|"inhibits"| PIKFYVE

Outgoing (82)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
ALS	targets	disease	0.95
ALS	therapeutic_target	entity	0.95
MCOLN1	regulates	gene	0.90
PtdIns(3,5)P2	produces	protein	0.90
ALS	mitigates	disease	0.90
Disease Progression	inhibits	phenotype	0.90
LRRK2	regulates	protein	0.85
Motor Neuron Degeneration	involved_in	process	0.80
AMYOTROPHIC LATERAL SCLEROSIS	causes	disease	0.80
ALS	implicated_in	disease	0.80
Protein Clearance	activates	pathway	0.80
Als	inhibits	disease	0.75
Amyotrophic Lateral Sclerosis	inhibits	disease	0.75
Neuronal Function	regulates	process	0.75
neurons	expressed_in	cell_type	0.70
AUTOPHAGY	regulates	process	0.70
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	activates	disease	0.65
Ms	activates	disease	0.65
Dementia	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Als	activates	disease	0.65
Tumor	activates	disease	0.65
Amyotrophic Lateral Sclerosis	treats	disease	0.65
Melanoma	activates	disease	0.65
ALS	activates	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Amyotrophic Lateral Sclerosis	protects_against	disease	0.65
FUS	inhibits	gene	0.60
TARDBP	inhibits	gene	0.60
Exocytosis	activates	pathway	0.60
Autophagy	therapeutic_target	pathway	0.60
LRRK2	activates	gene	0.60
ELAVL4	activates	gene	0.60
MAPT	activates	gene	0.60
Autophagy	activates	pathway	0.60
Autophagy	inhibits	pathway	0.60
MET	activates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
C9ORF72	inhibits	gene	0.60
ALS	inhibits	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
DEMENTIA	activates	gene	0.60
Glutamate Signaling	activates	pathway	0.60
Stem Cell	activates	pathway	0.60
AMYOTROPHIC LATERAL SCLEROSIS	treats	gene	0.60

Incoming (51)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
AMPK	activates	protein	0.80
C9ORF72	inhibits	gene	0.70
ALS	inhibits	gene	0.70
GABARAP	activates	gene	0.60
FUS	inhibits	gene	0.60
ENDOSOMES	activates	gene	0.60
PTEN	activates	gene	0.60
MOTOR NEURONS	inhibits	gene	0.60
UBIQUITIN	inhibits	gene	0.60
TARDBP	inhibits	gene	0.60
NEURODEGENERATION	activates	gene	0.60
TAU	activates	gene	0.60
ELAVL4	activates	gene	0.60
MAPT	activates	gene	0.60
AUTOPHAGY	activates	gene	0.60
UBIQUITIN	treats	gene	0.60
AND	inhibits	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	inhibits	gene	0.60
DEMENTIA	activates	gene	0.60
NEURON	inhibits	gene	0.60
ALS	protects_against	gene	0.60
C9ORF72	protects_against	gene	0.60
FUS	protects_against	gene	0.60
ACTB	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
EIF4EBP1	activates	gene	0.60
GFP	activates	gene	0.60
GUSB	activates	gene	0.60
HEXB	activates	gene	0.60
LC3	activates	gene	0.60
LDL	activates	gene	0.60
LGALS3	activates	gene	0.60
LRP2	activates	gene	0.60
MAP1LC3	activates	gene	0.60
MCOLN1	activates	gene	0.60
MTORC1	activates	gene	0.60
rapamycin	targets	drug	0.60
CRLS1	activates	gene	0.60
disease	inhibits	disease	0.50
Exocytosis	activates	pathway	0.50
NEURONS	inhibits	concept	0.50
Tdp-43	inhibits	pathway	0.50
amyotrophic lateral sclerosis	inhibits	gene	0.50
disease	activates	disease	0.50
Melanoma	activates	disease	0.50
Neuron	inhibits	cell_type	0.50
GLUTAMATE	inhibits	concept	0.50
benchmark_ot_ad_answer_key:PIKFYVE	data_in	dataset_row	0.00

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
PIKFYVE Inhibition Activates Aggregate Exocytosis via PI(3,5	0.559	neurodegeneration	How does PIKFYVE inhibition activate unc
C9orf72-SMCR8-WDR41 Complex Dysfunction in C9-ALS Rescued by	0.537	neurodegeneration	How does PIKFYVE inhibition activate unc

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.559

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PIKFYVE

Understanding Entity Pages

Wiki Pages (7)

Mechanisms Dashboard

FIG4 Protein

FIG4 — FIG4 Phosphatase Homolog

Spinal Cord Motor Neurons

ELAVL4 Gene

MCOLN1 — Mucolipin-1 (TRPML1)