Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SNCAPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SNCAPROTEIN |
| Target Class | Structural Protein |
| Function | is a presynaptic protein of the central nervous system year: 1995 doi: 10. |
| Mechanism of Action | Immunotherapy targeting alpha-synuclein aggregates or small molecules preventing aggregation |
| Druggability | Medium (0.49) |
| Clinical Stage | Phase II |
| GeneCards | SNCAPROTEIN |
| Human Protein Atlas | SNCAPROTEIN |
| Associated Diseases | AD, Aging, ALI, Alpha-Synucleinopathies, Als |
| Known Drugs/Compounds | ACI-7104.056, AFFITOPE PD01A, ASO, Cinpanemab, D-520, levodopa |
| Interactions | ABCA7, ABCD3, ACETYL-COA, ACLY, aco2, ACO2 |
| SciDEX Target | View Target Profile (8 clinical trials) |
| SciDEX Hypotheses | SNCA conformer propagation across PD, DLB, and MSA Exosomal SNCA Propagation from Lysosome-Compromise SNCA Aggregation Hijacks the Endosomal Sorting Com (+8 more) |
| KG Connections | 2840 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SNCAPROTEIN["SNCAPROTEIN"]
neurodegeneration["neurodegeneration"]
SNCAPROTEIN -->|"implicated_in"| neurodegeneration
style SNCAPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning SNCAPROTEIN in their description or question text
No additional research found