Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SNCB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SNCB |
| Full Name | Beta-Synuclein |
| Chromosome | 5q35.2 |
| Function | Beta-synuclein is expressed at high levels in the brain, particularly in presynaptic terminals where it performs several important functions: |
| Molecular Weight | 14 kDa |
| Amino Acids | 134 aa |
| UniProt ID | P37840 |
| NCBI Gene ID | 6622 |
| Ensembl ID | ENSG00000100030 |
| OMIM | 163890 |
| GeneCards | SNCB |
| Human Protein Atlas | SNCB |
| Protein Length | 134 amino acids |
| Associated Diseases | neurodegeneration |
| KG Connections | 28 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SNCB["<b>SNCB</b>"]
Traumatic_Brain_Injury{"Traumatic Brain Injury"}
SNCB -->|"expressed_in"| Traumatic_Brain_Injury
SNCG(["SNCG"])
SNCB -->|"expressed_in"| SNCG
STMN1(["STMN1"])
SNCB -->|"expressed_in"| STMN1
GAP43(["GAP43"])
SNCB -->|"expressed_in"| GAP43
HSPE1(["HSPE1"])
SNCB -->|"expressed_in"| HSPE1
BRAIN_INJURY(["BRAIN INJURY"])
SNCB -->|"expressed_in"| BRAIN_INJURY
NDUFS6(["NDUFS6"])
NDUFS6 -->|"expressed_in"| SNCB
LDHB(["LDHB"])
LDHB -->|"expressed_in"| SNCB
MAPT(["MAPT"])
MAPT -->|"expressed_in"| SNCB
GENES(["GENES"])
GENES -->|"expressed_in"| SNCB
style SNCB fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8| Target | Relation | Type | Str |
|---|---|---|---|
| Traumatic Brain Injury | expressed_in | disease | 0.65 |
| SNCG | expressed_in | gene | 0.60 |
| STMN1 | expressed_in | gene | 0.60 |
| GAP43 | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| NDUFS6 | expressed_in | gene | 0.60 |
| BRAIN INJURY | expressed_in | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| LDHB | expressed_in | gene | 0.60 |
| Temporal Lobe | expressed_in | brain_region | 0.55 |
| Frontal Lobe | expressed_in | brain_region | 0.55 |
| Cortex | expressed_in | brain_region | 0.55 |
| SNCG | co_expressed_with | protein | 0.50 |
| STMN1 | co_expressed_with | gene | 0.50 |
| Proteins | expressed_in | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NDUFS6 | expressed_in | gene | 0.60 |
| MAPT | expressed_in | gene | 0.60 |
| GAP43 | expressed_in | gene | 0.60 |
| HSPE1 | expressed_in | gene | 0.60 |
| STMN1 | expressed_in | gene | 0.60 |
| LDHB | expressed_in | gene | 0.60 |
| GENES | expressed_in | gene | 0.60 |
| MAPT | co_expressed_with | gene | 0.50 |
| NDUFS6 | co_expressed_with | gene | 0.50 |
| GAP43 | co_mentioned | gene | 0.40 |
| MAPT | co_mentioned | gene | 0.40 |
| NDUFS6 | co_mentioned | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||