gene

HSPE1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSPE1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

114Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for HSPE1 — Heat Shock Protein Family E Member 1

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🧬 Gene Info

Gene Symbol	HSPE1
Full Name	Heat Shock Protein Family E Member 1
Chromosome	2q33.1
Protein Type	Chaperone
Function	is a mitochondrial co-chaperone protein that functions as a heptameric ring complex together with HSP60 (encoded by HSPD1).
Primary Expression	Ubiquitous, high in brain
Subcellular Localization	Mitochondria (matrix)
Molecular Weight	10 kDa
UniProt ID	P61604
NCBI Gene ID	3336
OMIM	600351
GeneCards	HSPE1
Human Protein Atlas	HSPE1
Alias	HSP10, Cpn10, GroES
Protein Class	Chaperone, Co-chaperone
Associated Diseases	Alzheimer
Interactions	OPA1, LAMP2, BNIP3L, SIRT1, HTRA2, PARK2
KG Connections	114 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: HSPE1 — AlphaFold P61604 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HSPE1["HSPE1"] -.->|"inhibits"| Heart_Failure["Heart Failure"]
    HSPE1["HSPE1"] -.->|"inhibits"| Ms["Ms"]
    HSPE1["HSPE1"] -->|"expressed in"| Lymphoma["Lymphoma"]
    HSPE1["HSPE1"] -->|"expressed in"| Ms_1["Ms"]
    HSPE1["HSPE1"] -->|"expressed in"| Cancer["Cancer"]
    HSPE1["HSPE1"] -->|"expressed in"| Tumor["Tumor"]
    BNIP3["BNIP3"] -.->|"inhibits"| HSPE1["HSPE1"]
    VDAC1["VDAC1"] -.->|"inhibits"| HSPE1["HSPE1"]
    FUNDC1["FUNDC1"] -.->|"inhibits"| HSPE1["HSPE1"]
    TOMM20["TOMM20"] -.->|"inhibits"| HSPE1["HSPE1"]
    style HSPE1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (61)

Target	Relation	Type	Str
Heart Failure	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Lymphoma	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Alzheimer	associated_with	disease	0.65
Traumatic Brain Injury	expressed_in	disease	0.65
OPA1	inhibits	gene	0.60
LAMP2	inhibits	gene	0.60
BNIP3L	inhibits	gene	0.60
SIRT1	inhibits	gene	0.60
HTRA2	inhibits	gene	0.60
PARK2	inhibits	gene	0.60
PINK1	inhibits	gene	0.60
TIMM17A	inhibits	gene	0.60
EIF2A	inhibits	gene	0.60
TFAM	inhibits	gene	0.60
ULK1	inhibits	gene	0.60
TIMM10	inhibits	gene	0.60
DNM1L	inhibits	gene	0.60
HSP90AB1	expressed_in	gene	0.60
HSP70	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
HSPA1A	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSP90AA1	biomarker_for	gene	0.60
OPTN	biomarker_for	gene	0.60
HSP60	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
NDUFS6	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
Unfolded Protein Response	inhibits	pathway	0.60
Mitophagy	inhibits	pathway	0.60
Mtor	inhibits	pathway	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
Apoptosis	expressed_in	pathway	0.60
Unfolded Protein Response	expressed_in	pathway	0.60
Nf-Κb	expressed_in	pathway	0.60
Phagocytosis	expressed_in	pathway	0.60
ALZHEIMER	associated_with	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
MICRORNAS	associated_with	gene	0.60

Incoming (53)

Source	Relation	Type	Str
BNIP3	inhibits	gene	0.60
VDAC1	inhibits	gene	0.60
FUNDC1	inhibits	gene	0.60
TOMM20	inhibits	gene	0.60
TIMM9	inhibits	gene	0.60
TIMM17B	inhibits	gene	0.60
OMA1	inhibits	gene	0.60
TIMM23	inhibits	gene	0.60
MTOR	inhibits	gene	0.60
NRF1	inhibits	gene	0.60
HSPD1	inhibits	gene	0.60
MFN2	inhibits	gene	0.60
MFF	inhibits	gene	0.60
BECN1	inhibits	gene	0.60
LONP1	inhibits	gene	0.60
CEBPB	inhibits	gene	0.60
SPG7	inhibits	gene	0.60
MAP1LC3A	inhibits	gene	0.60
DDIT3	inhibits	gene	0.60
JUN	inhibits	gene	0.60
TIMM50	inhibits	gene	0.60
HSPA9	inhibits	gene	0.60
TIMM22	inhibits	gene	0.60
UBIQUITIN	expressed_in	gene	0.60
BAG3	expressed_in	gene	0.60
UBC	expressed_in	gene	0.60
HSPD1	expressed_in	gene	0.60
DNAJC7	expressed_in	gene	0.60
HSPA6	expressed_in	gene	0.60
DNAJB1	expressed_in	gene	0.60
IKBKB	expressed_in	gene	0.60
HSPA1B	expressed_in	gene	0.60
NDUFS4	biomarker_for	gene	0.60
HSP70	expressed_in	gene	0.60
HSPA1L	expressed_in	gene	0.60
DNAJC10	expressed_in	gene	0.60
HSPH1	expressed_in	gene	0.60
HSP90AB1	expressed_in	gene	0.60
NDUFS6	expressed_in	gene	0.60
MAPT	expressed_in	gene	0.60
SNCB	expressed_in	gene	0.60
SNCG	expressed_in	gene	0.60
STMN1	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
MITOPHAGY	inhibits	gene	0.60
CANCER	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
NF-ΚB	expressed_in	gene	0.60
PHAGOCYTOSIS	expressed_in	gene	0.60
GENES	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HSPE1

Understanding Entity Pages

Summary

Wiki Pages (17)

HSPE1 — Heat Shock Protein Family E Member 1

STMN1 — Stathmin 1

SNCG Gene — Gamma-Synuclein

SNCB Gene

Stathmin 1 Protein

HSP60 (Heat Shock Protein 60)

DnaJ Heat Shock Protein Family (Hsp40) Member C7

HSPA6

DNAJC10 Gene

HSPE1 Protein

TIMM22 Protein

Hsp10 Protein

HSPD2 Gene

NDUFS4 Gene

TIMM50 Gene - Mitochondrial Import Protein