protein

SP1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SP1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Sp1 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.

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🔬 Protein Info

Gene Symbol	SP1PROTEIN
Full Name	Sp1
Protein Type	Protein
Function	is a zinc finger transcription factor that plays crucial roles in regulating gene expression in neuronal cells.
UniProt ID	Search UniProt
GeneCards	SP1PROTEIN
Human Protein Atlas	SP1PROTEIN
DNA-Binding Domain	Three C2H2-type zinc finger motifs at the C-terminus that recognize GC-box sequences (5'-GGGGCGG-3')
Transactivation Domain	Rich in glutamine at the N-terminus, responsible for recruiting transcriptional co-activators
Domain for Protein-Protein Interactions	Enables interaction with other transcription factors and co-factors
Direct Binding	Binds to GC-rich promoter elements to activate transcription
Chromatin Remodeling	Interacts with histone acetyltransferases (HATs) and histone deacetylases (HDACs)
Cooperative Binding	Multiple Sp1 molecules can bind cooperatively to enhance transcriptional activation
Post-Translational Modifications	Phosphorylation, acetylation, and sumoylation regulate its activity[@tan2009]
[BACE1](/entities/bace1) Expression	Modulates BACE1 (beta-secretase) transcription, the rate-limiting enzyme in amyloid-beta generation
Associated Diseases	Als, Alzheimer, Ms
Known Drugs/Compounds	Glucosamine
Interactions	APP, ATP2A3, CANCER, CHOP, DKK1, DNA
KG Connections	156 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: SP1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Sp1 Protein

protein · 780 words

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Pathway Diagram

graph TD
    SP1PROTEIN["SP1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    SP1PROTEIN -->|"implicated_in"| neurodegeneration
    style SP1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SP1PROTEIN in their description or question text

No additional research found