gene

SP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

19Connections

0Hypotheses

0Analyses

13Outgoing

6Incoming

Summary

SP3 is a gene implicated in neurodegeneration research. Key relationships include: activates, interacts with, expressed in. Associated with ALS, Als, Cancer. Connected to 13 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SP3
Full Name	Specificity Protein 3
Protein Type	Transcription Factor
Function	SP3 is a sequence-specific transcription factor that binds to GC-rich promoter elements (GC boxes) and regulates gene expression.
Primary Expression	all CA regions and dentate gyrus - Cerebellum: Present in Purkinje cells and granule cells - Substantia Nigra: Detected in dopaminergic neuron
Ensembl ID	ENSG00000172845
GeneCards	SP3
Human Protein Atlas	SP3
Transactivation Domains	N-terminal regions required for transcriptional activation
Zinc Finger Domain	C-terminal DNA-binding domain with three C2H2-type zinc fingers
Repressor Domain	Contains domains that can recruit co-repressors
Amyloid Regulation	SP3 regulates APP (Amyloid Precursor Protein) expression
[Tau](/proteins/tau) Pathology	Involved in regulation of tau-associated genes
Neuroinflammation	Controls inflammatory gene expression in microglia
Associated Diseases	neurodegeneration
Interactions	ATP2A3, DNA, CANCER
KG Connections	19 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

SP3 — Specificity Protein 3

gene · 524 words

→

DLB, Parkinson's Disease, and Alzheimer's Disease: Cross-Disease Comparison Matrix

disease · 3237 words

→

Section 234: Advanced Acupuncture and Traditional Chinese Medicine Physical Modalities in CBS/PSP

therapeutic · 2430 words

→

Pathway Diagram

graph TD
    SP3["<b>SP3</b>"]
    Cancer{"Cancer"}
    SP3 -->|"activates"| Cancer
    Ms{"Ms"}
    SP3 -->|"activates"| Ms
    Als{"Als"}
    SP3 -->|"activates"| Als
    ALS{"ALS"}
    SP3 -->|"activates"| ALS
    ATP2A3["ATP2A3"]
    SP3 -->|"interacts with"| ATP2A3
    SP1["SP1"]
    SP3 -->|"expressed in"| SP1
    DNA["DNA"]
    SP3 -->|"interacts with"| DNA
    CANCER["CANCER"]
    SP3 -->|"activates"| CANCER
    Ca3["Ca3"]
    SP3 -->|"expressed in"| Ca3
    neurodegeneration["neurodegeneration"]
    SP3 -->|"implicated in"| neurodegeneration
    SP1 -->|"expressed in"| SP3
    ATP2A3 -->|"interacts with"| SP3
    DNA -->|"interacts with"| SP3
    AND["AND"]
    AND -->|"expressed in"| SP3
    style SP3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (13)

Target	Relation	Type	Str
ATP2A3	activates	gene	0.95
ATP2A3	binds	gene	0.95
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
ALS	activates	disease	0.65
ATP2A3	interacts_with	gene	0.60
SP1	expressed_in	gene	0.60
DNA	interacts_with	gene	0.60
CANCER	activates	gene	0.60
AND	expressed_in	gene	0.60
Epithelial	activates	cell_type	0.60
Ca3	expressed_in	brain_region	0.55

Incoming (6)

Source	Relation	Type	Str
SP1	expressed_in	gene	0.60
ATP2A3	interacts_with	gene	0.60
ATP2A3	activates	entity	0.60
SP1	activates	entity	0.60
DNA	interacts_with	gene	0.60
CANCER	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SP3