gene

SP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

160Connections

0Hypotheses

0Analyses

50Outgoing

47Incoming

Summary

SP1 is a gene implicated in neurodegeneration research. Key relationships include: expressed in, activates, associated with. Associated with ALS, Aging, Als. Connected to 105 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	SP1
Full Name	SP1 (Specificity Protein 1)
Aliases	Specificity Protein 1
Protein Type	Gene
Function	The SP1 gene encodes Specificity Protein 1 (Sp1), a zinc finger transcription factor that binds to GC-rich promoter elements and regulates the expression of numerous genes including housekeeping genes
Pathways	Akt, Epigenetic, Pi3K
NCBI Gene ID	Search NCBI
GeneCards	SP1
Human Protein Atlas	SP1
Associated Diseases	Als, Alzheimer, Ms
Known Drugs/Compounds	Glucosamine
Interactions	ATP2A3, PKC, LRRK2, HSF1, STAT3, DKK1
KG Connections	159 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SP1["SP1"]
    SP1 -->|"activates"| Cancer["Cancer"]
    SP1 -->|"activates"| Ms["Ms"]
    SP1 -->|"activates"| Als["Als"]
    SP1 -->|"expressed in"| Tumor["Tumor"]
    CLCN1["CLCN1"] -->|"regulates"| SP1
    SP3["SP3"] -->|"expressed in"| SP1
    ATP2A3["ATP2A3"] -->|"interacts"| SP1
    PI3K["PI3K"] -->|"regulates"| SP1
    SPHK1["SPHK1"] -->|"activates"| SP1
    ERK["ERK"] -->|"activates"| SP1
    AGING["AGING"] -->|"regulates"| SP1
    FOS["FOS"] -->|"target for"| SP1
    HIPPO["HIPPO"] -->|"expressed in"| SP1
    RELA["RELA"] -->|"expressed in"| SP1

Outgoing (112)

Target	Relation	Type	Str
ATP2A3	activates	gene	0.95
ATP2A3	binds	gene	0.95
Cancer	activates	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Leukemia	activates	disease	0.65
Aging	regulates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Parkinson	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Ataxia	expressed_in	disease	0.65
Cardiovascular	activates	disease	0.65
Neurodegeneration	expressed_in	disease	0.65
Hypertension	expressed_in	disease	0.65
Als	biomarker_for	disease	0.65
Ms	biomarker_for	disease	0.65
Cancer	biomarker_for	disease	0.65
Carcinoma	biomarker_for	disease	0.65
ALS	activates	disease	0.65
Obesity	activates	disease	0.65
Inflammation	contributes_to	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
SP3	expressed_in	gene	0.60
ATP2A3	interacts_with	gene	0.60
AKT	regulates	gene	0.60
PTEN	expressed_in	gene	0.60
AKT	expressed_in	gene	0.60
PKC	activates	gene	0.60
SIRT1	therapeutic_target	gene	0.60
BRCA1	therapeutic_target	gene	0.60
IRF7	expressed_in	gene	0.60
PPARGC1A	expressed_in	gene	0.60
ATF4	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
NFKB1	expressed_in	gene	0.60
APOE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
KIF13A	associated_with	gene	0.60
TRIM24	associated_with	gene	0.60

Incoming (48)

Source	Relation	Type	Str
Glucosamine	modulates	compound	0.80
SP3	expressed_in	gene	0.60
ATP2A3	interacts_with	gene	0.60
PI3K	regulates	gene	0.60
SPHK1	activates	gene	0.60
FOS	therapeutic_target	gene	0.60
RELA	expressed_in	gene	0.60
MYC	expressed_in	gene	0.60
ATP7A	expressed_in	gene	0.60
SOD1	expressed_in	gene	0.60
DUSP10	associated_with	gene	0.60
MAP1S	associated_with	gene	0.60
PSP	associated_with	gene	0.60
EGR1	expressed_in	gene	0.60
EGR1	activates	gene	0.60
CHOP	activates	gene	0.60
SMAD2	regulates	gene	0.60
ATP2A3	activates	entity	0.60
NESTIN	activates	gene	0.60
DKK1	inhibits	gene	0.60
STAT3	activates	gene	0.60
APP	activates	gene	0.60
TREM2	contributes_to	gene	0.60
SOD2	contributes_to	gene	0.60
CXCL1	contributes_to	gene	0.60
LRRK2	activates	gene	0.60
CXCL1	implicated_in	gene	0.60
REG3A	implicated_in	gene	0.60
SOD2	implicated_in	gene	0.60
LRRK2	interacts_with	gene	0.60
LRRK2	expressed_in	gene	0.60
ERK	activates	gene	0.60
AGING	regulates	gene	0.60
HIPPO	expressed_in	gene	0.60
P53	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
ASTROCYTES	associated_with	gene	0.60
PARKINSON'S DISEASE	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
NEURODEGENERATION	expressed_in	gene	0.60
MIRNAS	biomarker_for	gene	0.60
PROTEIN MISFOLDING	activates	gene	0.60
DNA	interacts_with	gene	0.60
CANCER	activates	entity	0.60
AND	expressed_in	gene	0.60
AND	activates	gene	0.60
SGMS1	activates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SP1

Understanding Entity Pages

Summary

Wiki Pages (21)

SP1 (Specificity Protein 1)

NPM1 Gene

CBS/PSP Clinical Trials Guide

Section 152: Advanced Robotics and Assistive Devices in CBS/PSP

Section 147: Telehealth and Remote Monitoring in CBS/PSP

PEN2 Gene

gba

Huntingtin Protein (HTT)

TOR1A Gene

HRAS (Harvey Rat Sarcoma Viral Oncogene Homolog)

HDAC6 Protein

Trinucleotide Repeat Expansion Disorders

HDAC6 Protein

Protein O-GlcNAcylation Pathway in Neurodegeneration

PNMT Protein

Sphingolipid Metabolism in Neurodegeneration

DLB, Parkinson's Disease, and Alzheimer's Disease: Cross-Disease Comparison Matrix

OTULIN-Tau Regulation Pathway

Epigenetic Changes in PSP