Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EPITHELIAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | EPITHELIAL |
graph TD
EPITHELIAL["EPITHELIAL"]
style EPITHELIAL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
EPITHELIAL -->|"expressed in"| Basal_Ganglia((Basal Ganglia))
EPITHELIAL -->|"expressed in"| Gray_Matter((Gray Matter))
EPITHELIAL -->|"expressed in"| Brainstem((Brainstem))
EPITHELIAL -->|"expressed in"| Substantia_Nigra((Substantia Nigra))
CPT1A([CPT1A]) -->|"regulates"| EPITHELIAL
MITOCHONDRIA([MITOCHONDRIA]) -->|"activates"| EPITHELIAL
SQSTM1([SQSTM1]) -->|"regulates"| EPITHELIAL
PPARG([PPARG]) -->|"regulates"| EPITHELIAL
RPS6KB1([RPS6KB1]) -->|"regulates"| EPITHELIAL
LRP2([LRP2]) -->|"regulates"| EPITHELIAL
NADH([NADH]) -->|"regulates"| EPITHELIAL
ATG([ATG]) -->|"regulates"| EPITHELIAL
PPARA([PPARA]) -->|"regulates"| EPITHELIAL
EIF4EBP1([EIF4EBP1]) -->|"regulates"| EPITHELIAL| Target | Relation | Type | Str |
|---|---|---|---|
| Basal Ganglia | expressed_in | brain_region | 0.50 |
| Gray Matter | expressed_in | brain_region | 0.50 |
| Substantia Nigra | expressed_in | brain_region | 0.50 |
| Brainstem | expressed_in | brain_region | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| EMP1 | regulates | gene | 0.60 |
| TP53 | associated_with | gene | 0.60 |
| AQP4 | expressed_in | gene | 0.60 |
| TCR | expressed_in | gene | 0.60 |
| APOPTOSIS | inhibits | gene | 0.60 |
| RNA | inhibits | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| UNC5B | activates | gene | 0.60 |
| RNA | regulates | gene | 0.60 |
| PRMT1 | therapeutic_target | gene | 0.60 |
| AUTOPHAGY | therapeutic_target | gene | 0.60 |
| PRMT5 | therapeutic_target | gene | 0.60 |
| DNA | therapeutic_target | gene | 0.60 |
| RNA | activates | gene | 0.60 |
| TUBB3 | activates | gene | 0.60 |
| JUN | therapeutic_target | gene | 0.60 |
| ST6GAL1 | regulates | gene | 0.60 |
| APP | therapeutic_target | gene | 0.60 |
| FUT8 | regulates | gene | 0.60 |
| TCR | therapeutic_target | gene | 0.60 |
| EGFR | therapeutic_target | gene | 0.60 |
| ERBB3 | therapeutic_target | gene | 0.60 |
| BACE1 | therapeutic_target | gene | 0.60 |
| LOX/LOXL1-4 | therapeutic_target | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| LOXL3 | therapeutic_target | gene | 0.60 |
| IL-1 | activates | gene | 0.60 |
| MLCK | activates | gene | 0.60 |
| CLDN1 | activates | gene | 0.60 |
| OCLN | activates | gene | 0.60 |
| DACH1 | inhibits | gene | 0.60 |
| CD44 | inhibits | gene | 0.60 |
| SALL1 | expressed_in | gene | 0.60 |
| WT1 | expressed_in | gene | 0.60 |
| PAX2 | expressed_in | gene | 0.60 |
| SP3 | activates | gene | 0.60 |
| SP1 | activates | gene | 0.60 |
| ATP2A3 | activates | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| CYP2E1 | expressed_in | gene | 0.60 |
| ROS | expressed_in | gene | 0.60 |
| COMPLEMENT | activates | gene | 0.60 |
| STAT3 | activates | gene | 0.60 |
| SRC | inhibits | gene | 0.60 |
| SOX2 | inhibits | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| YAP | inhibits | gene | 0.60 |
| VDR | activates | gene | 0.60 |
| SLC7A11 | inhibits | gene | 0.60 |
| CERS2 | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning EPITHELIAL in their description or question text
No additional research found