concept

SRT2104

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SRT2104: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

3Analyses

25Outgoing

1Incoming

0Experiments

5Debates

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💡 Concept Info

Name	SRT2104
Key Genes/Proteins	PINK1, PRKN, SIRT1, TP53
Related Diseases	Age-Related Degeneration In Auditory System, Age-related hearing loss, Age-Related Neurodegeneration, Alzheimer disease, Cellular Senescence
Related Pathways	SIRT1 activation

Pathway Diagram

graph TD
    SRT2104[SRT2104]
    SRT2104 -->|activates| SIRT1[SIRT1]
    SRT2104 -->|suppresses| Cellular_Senescence[Cellular Senescence]
    SRT2104 -->|upregulates| PINK1[PINK1]
    SRT2104 -->|upregulates| PRKN[PRKN]
    SRT2104 -->|downregulates| TP53[TP53]
    SRT2104 -.protects against.-> Age_Related_Neurodegeneration[Age-Related Neurodegeneration]
    SRT2104 -->|upregulates| Mitochondrial_Membrane_Potenti[Mitochondrial Membrane Potential]
    SRT2104 -.protects against.-> senescence[senescence]
    SRT2104 -->|treats| Age_Related_Degeneration_In_Au[Age-Related Degeneration In Auditory System]
    SIRT1 -->|interacts| SRT2104

Outgoing (25)

Target	Relation	Type	Str
SIRT1	activates	protein	0.95
SIRT1	activates	protein	0.95
Cellular Senescence	suppresses	phenotype	0.93
PRKN	upregulates	gene	0.92
PINK1	upregulates	gene	0.92
TP53	downregulates	gene	0.92
Age-Related Neurodegeneration	protects_against	disease	0.90
Mitochondrial Membrane Potential	upregulates	biomarker	0.90
senescence	protects_against	phenotype	0.90
Age-Related Degeneration In Auditory System	treats	disease	0.88
auditory cells	expressed_in	cell_type	0.85
PINK1	upregulates	protein	0.80
PRKN	upregulates	protein	0.80
BNIP3	upregulates	protein	0.80
TP53	downregulates	protein	0.80
Cdkn1A	downregulates	protein	0.80
auditory hair cells	protects_against	cell_type	0.80
mitochondrial membrane potential	associated_with	phenotype	0.80
Age-related hearing loss	treats	disease	0.80
Age-related hearing loss	treats	disease	0.75
age-related hearing loss	protects_against	disease	0.75
cognitive impairment	therapeutic_target_for	phenotype	0.70
cognitive improvement	causes	phenotype	0.70
SIRT1 activation	causes	mechanism	0.50
Alzheimer disease	therapeutic_target_for	disease	0.50