Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SRT2104: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| SIRT1 | activates | protein | 0.95 |
| SIRT1 | activates | protein | 0.95 |
| Cellular Senescence | suppresses | phenotype | 0.93 |
| PINK1 | upregulates | gene | 0.92 |
| PRKN | upregulates | gene | 0.92 |
| TP53 | downregulates | gene | 0.92 |
| Age-Related Neurodegeneration | protects_against | disease | 0.90 |
| Mitochondrial Membrane Potential | upregulates | biomarker | 0.90 |
| senescence | protects_against | phenotype | 0.90 |
| Age-Related Degeneration In Auditory System | treats | disease | 0.88 |
| auditory cells | expressed_in | cell_type | 0.85 |
| Age-related hearing loss | treats | disease | 0.80 |
| PINK1 | upregulates | protein | 0.80 |
| PRKN | upregulates | protein | 0.80 |
| BNIP3 | upregulates | protein | 0.80 |
| TP53 | downregulates | protein | 0.80 |
| Cdkn1A | downregulates | protein | 0.80 |
| auditory hair cells | protects_against | cell_type | 0.80 |
| mitochondrial membrane potential | associated_with | phenotype | 0.80 |
| Age-related hearing loss | treats | disease | 0.75 |
| age-related hearing loss | protects_against | disease | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||