Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TFEB Nuclear Translocation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| autophagy pathway | activates | pathway | 0.90 |
| neurodegenerative disease models | impairs | phenotype | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Mtorc1 | inhibits | protein | 0.90 |
| trehalose | activates | drug | 0.90 |
| mTORC1 dissociation from lysosomes | enables | process | 0.90 |
| mTORC1 | inhibits | pathway | 0.90 |
| AMPK | activates | pathway | 0.90 |
| AMPK activation | activates | pathway | 0.90 |
| Sulforaphane | mediates | compound | 0.88 |
| Reactive Oxygen Species | mediates | process | 0.85 |
| MTOR | inhibits | protein | 0.80 |
| mTORC1 inhibition | activates | process | 0.70 |
| MTOR inhibitors | activates | drug | 0.70 |
| mTOR | inhibits | pathway | 0.70 |
| rapamycin | activates | drug | 0.70 |
| calcineurin | activates | protein | 0.70 |
| HDAC9 | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis | 0.779 | neurodegeneration | What molecular mechanism causes VCP muta |
| mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuc | 0.640 | neurodegeneration | - |
| TFEB Nuclear Translocation Clears α-Synuclein via Autophagy- | 0.580 | neurodegeneration | Test Preregistration Analysis |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387
proteomics | 2026-04-16 | 19 hypotheses Top: 0.591
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.740
neurodegeneration | 2026-04-08 | 3 hypotheses Top: 0.470
neurodegeneration | 2026-04-07 | 5 hypotheses Top: 0.718
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 [PMID:41400694] | Jacqmin T, Gilis F, Albert M, Gaussin JF | J Cell Biol | 2026 | 0 |
| β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by tar [PMID:41501416] | Wang Y, Sun Y, Wang CY, Cao M, Hao R et | Acta Pharmacol Sin | 2026 | 0 |
| Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degener [PMID:41536620] | Wang X, Sun H, Xiao W, Zhang Y, Lu X et | Noncoding RNA Res | 2026 | 0 |
| AMPK promotes TFEB transcriptional activity through dephosphorylation at both MT [PMID:41661247] | Negoita F, Fraguas Bringas C, Hellberg K | Autophagy | 2026 | 0 |
| Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeosta [PMID:41838890] | Cao P, Niu M, Zhu H, Zhang C, Zhu H et a | Hepatology | 2026 | 0 |
Multi-agent debates referencing this entity
completed · Rounds: 5 · Score: 0.50 · 2026-04-25
closed · Rounds: 4 · Score: 0.61 · 2026-04-21
closed · Rounds: 4 · Score: 0.80 · 2026-04-21
closed · Rounds: 4 · Score: 0.73 · 2026-04-21
closed · Rounds: 4 · Score: 0.65 · 2026-04-21
closed · Rounds: 4 · Score: 0.60 · 2026-04-21
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
closed · Rounds: 4 · Score: 0.71 · 2026-04-16
Hypotheses and analyses mentioning TFEB Nuclear Translocation in their description or question text
No additional research found