entity

TFEB nuclear translocation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TFEB nuclear translocation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections

3Hypotheses

3Analyses

0Outgoing

9Incoming

0Experiments

3Debates

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Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (9)

Source	Relation	Type	Str
AMPK	activates	pathway	0.90
AMPK activation	activates	pathway	0.90
mTORC1	inhibits	pathway	0.90
trehalose	activates	drug	0.90
Sulforaphane	mediates	compound	0.88
Reactive Oxygen Species	mediates	process	0.85
MTOR	inhibits	protein	0.80
calcineurin	activates	protein	0.70
mTORC1 inhibition	activates	process	0.70

Targeting Hypotheses (3)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TFEB Nuclear Translocation to Reset Lysosomal-Hypoxia Axis	0.779	neurodegeneration	What molecular mechanism causes VCP muta
mTORC1 Displacement from Lysosomal Membrane Enables TFEB Nuc	0.640	neurodegeneration	-
TFEB Nuclear Translocation Clears α-Synuclein via Autophagy-	0.580	neurodegeneration	Test Preregistration Analysis

Mentioning Analyses (3)

Scientific analyses that reference this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

neurodegeneration | 2026-04-25 | 6 hypotheses Top: 0.387

How do different organelle-specific autophagy pathways coordinate during neurode

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.772

How does controlled lysosomal membrane permeabilization induce autophagy without

neurodegeneration | 2026-04-07 | 7 hypotheses Top: 0.690

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Maspardin/SPG21 controls lysosome motility and TFEB phosphorylation through RAB7 [PMID:41400694]	Jacqmin T, Gilis F, Albert M, Gaussin JF	J Cell Biol	2026
β-Sitosterol ameliorates metabolic dysfunction-associated steatohepatitis by tar [PMID:41501416]	Wang Y, Sun Y, Wang CY, Cao M, Hao R et	Acta Pharmacol Sin	2026
Epigenetic H3K4me3 activation of miR-155-5p promotes intervertebral disc degener [PMID:41536620]	Wang X, Sun H, Xiao W, Zhang Y, Lu X et	Noncoding RNA Res	2026
AMPK promotes TFEB transcriptional activity through dephosphorylation at both MT [PMID:41661247]	Negoita F, Fraguas Bringas C, Hellberg K	Autophagy	2026
Hepatic STEAP4 promotes liver regeneration by regulating lysosomal iron homeosta [PMID:41838890]	Cao P, Niu M, Zhu H, Zhang C, Zhu H et a	Hepatology	2026

Debates (3)

Multi-agent debates referencing this entity

Epigenetic clocks as biomarkers for Alzheimer disease and neurodegeneration

completed · Rounds: 5 · Score: 0.50 · 2026-04-25

The study shows trehalose causes lysosomal membrane permeabilization (LMP) that

closed · Rounds: 4 · Score: 0.61 · 2026-04-21

The abstract mentions multiple organelles synchronously present structural deran

closed · Rounds: 4 · Score: 0.80 · 2026-04-21

Related Research

Hypotheses and analyses mentioning TFEB nuclear translocation in their description or question text

No additional research found